Middle East Respiratory Syndrome Coronavirus Accessory Protein 4a Is a Type I Interferon Antagonist
Middle East Respiratory Syndrome Coronavirus Accessory Protein 4a Is a Type I Interferon Antagonist
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DOI：
10.1128/jvi.01845-13
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发表时间：
2013-11-01
影响因子：
5.4
通讯作者：
Mueller, Marcel A.
中科院分区：
文献类型：
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作者：
Niemeyer, Daniela;Zillinger, Thomas;Mueller, Marcel A.
中东呼吸综合征冠状病毒（MERS-CoV）引起严重的急性呼吸道感染，其流行病学尚不清楚。我们之前的研究表明，MERS-CoV抵消了人细支气管细胞的部分先天免疫反应。在这里，我们分析了辅助蛋白3、4a、4b和5抑制I型干扰素反应的能力。发现辅助蛋白4a在黑色素瘤分化相关蛋白5 （MDA5）激活水平上阻断干扰素诱导，可能是通过与双链RNA的直接相互作用。
Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe acute respiratory infection with as yet unclear epidemiology. We previously showed that MERS-CoV counteracts parts of the innate immune response in human bronchiolar cells. Here we analyzed accessory proteins 3, 4a, 4b, and 5 for their abilities to inhibit the type I interferon response. Accessory protein 4a was found to block interferon induction at the level of melanoma differentiation-associated protein 5 (MDA5) activation presumably by direct interaction with double-stranded RNA.