Sassafrins A-D, new antimicrobial azaphilones from the fungus Creosphaeria sassafras
Sassafrins A-D, new antimicrobial azaphilones from the fungus Creosphaeria sassafras
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DOI：
10.1016/j.tet.2004.12.031
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发表时间：
2005-02-14
期刊：
影响因子：
2.1
通讯作者：
Asakawa, Y
中科院分区：
文献类型：
--
作者：
Quang, DN;Hashimoto, T;Asakawa, Y
从子囊菌纲炭角菌科真菌Creosphaeria sassafras子座的甲醇提取物中分离得到4个新的氮杂菲酮类化合物，命名为sassaffins A-D（1-4）。其结构经2DNMR、HR-MS、IR、UV和CD光谱确证。本文还对黄樟素D（4）的生物合成途径进行了讨论。此外，所有化合物均表现出广谱抗菌活性。它们在C. sassafras支持这种真菌作为炭角菌科内一个独特属的成员的地位，与分子和形态特征相一致。(C)2004爱思唯尔有限公司保留所有权利。
Four new azaphilones named sassaffins A-D (1-4) were isolated from the methanol extract of the stromata of the fungus Creosphaeria sassafras (Xylariaceae, Ascomycetes). Their structures were elucidated by 2D NMR, HR-MS, IR, UV and CD spectroscopy. Sassafrin D (4) possesses a novel skeleton and its biosynthetic pathway is also discussed. In addition, all compounds showed broad-spectrum antimicrobial activity. Their apparently unique occurrence in C. sassafras supports the status of this fungus as a member of a distinct genus within the Xylariaceae, coinciding with molecular and morphological traits. (C) 2004 Elsevier Ltd. All rights reserved.