At-home self-collection of saliva, oropharyngeal swabs and dried blood spots for SARS-CoV-2 diagnosis and serology: Post-collection acceptability of specimen collection process and patient confidence in specimens
At-home self-collection of saliva, oropharyngeal swabs and dried blood spots for SARS-CoV-2 diagnosis and serology: Post-collection acceptability of specimen collection process and patient confidence in specimens
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DOI：
10.1371/journal.pone.0236775
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发表时间：
2020-08-05
期刊：
影响因子：
3.7
通讯作者：
Sullivan, Patrick Sean
中科院分区：
文献类型：
--
作者：
Valentine-Graves, Mariah;Hall, Eric;Sullivan, Patrick Sean
背景：需要采取措施，提高对SARS-CoV-2感染和免疫反应的检测便利性。在家中自行收集诊断标本提供了一种途径，使人们无需前往诊所或实验室即可检测SARS-CoV-2感染或免疫反应。在本研究之前，调查对象表示愿意自行采集样本进行新冠病毒相关检测，但假设的意愿可能与参与者采集样本后的采集后可接受性不同。方法153名美国成年人参与了一项研究，研究患者在临床医生通过远程医疗会议观察时自行采集三种诊断标本（唾液、口咽拭子（OPS）和干血斑（DBS）卡）的意愿和可行性。采集标本后，148名参与者参与了一项关于采集、包装和运输过程的可接受性以及他们对采集的用于covid相关实验室检测的样本的信心的调查。结果绝大多数参与者（b> 84%）报告唾液、OPS和DBS标本的收集、包装和运输是可以接受的。近十分之九（87%）的人报告有信心或非常有信心他们收集的标本足以进行实验室分析。在任何标本类型、包装和运输的可接受性或样品的置信度、性别、年龄、种族/民族或教育水平方面没有差异。结论：在不同的美国成年人群体中，自行采集标本进行SARS-CoV-2检测，并准备和运输标本进行分析是可以接受的。需要进一步完善材料和说明，以支持自行收集唾液、OPS和DBS标本进行新冠病毒相关检测。
Background Options to increase the ease of testing for SARS-CoV-2 infection and immune response are needed. Self-collection of diagnostic specimens at home offers an avenue to allow people to test for SARS-CoV-2 infection or immune response without traveling to a clinic or laboratory. Before this study, survey respondents indicated willingness to self-collect specimens for COVID-related tests, but hypothetical willingness can differ from post-collection acceptability after participants collect specimens. Methods 153 US adults were enrolled in a study of the willingness and feasibility of patients to self-collect three diagnostic specimens (saliva, oropharyngeal swab (OPS) and dried blood spot (DBS) card) while observed by a clinician through a telehealth session. After the specimens were collected, 148 participants participated in a survey about the acceptability of the collection, packing and shipping process, and their confidence in the samples collected for COVID-related laboratory testing. Results A large majority of participants (>84%) reported that collecting, packing and shipping of saliva, OPS, and DBS specimens were acceptable. Nearly nine in 10 (87%) reported being confident or very confident that the specimens they collected were sufficient for laboratory analysis.There were no differences in acceptability for any specimen type, packing and shipping, or confidence in samples, by gender, age, race/ethnicity, or educational level. Conclusions Self-collection of specimens for SARS-CoV-2 testing, and preparing and shipping specimens for analysis, were acceptable in a diverse group of US adults. Further refinement of materials and instructions to support self-collection of saliva, OPS and DBS specimens for COVID-related testing is needed.