Revised response criteria for myelofibrosis: International Working Group-Myeloproliferative Neoplasms Research and Treatment (IWG-MRT) and European LeukemiaNet (ELN) consensus report
Revised response criteria for myelofibrosis: International Working Group-Myeloproliferative Neoplasms Research and Treatment (IWG-MRT) and European LeukemiaNet (ELN) consensus report
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DOI：
10.1182/blood-2013-03-488098
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发表时间：
2013-08-22
期刊：
影响因子：
20.3
通讯作者：
Barosi, Giovanni
中科院分区：
文献类型：
--
作者：
Tefferi, Ayalew;Cervantes, Francisco;Barosi, Giovanni
本文件是国际工作组-骨髓增生性肿瘤研究和治疗（IWG-MRT）骨髓纤维化（MF）治疗反应标准的修订版，代表了IWG-MRT和欧洲白血病网的合作努力，目的是客观评估新药在诱导MF相关症状负荷（MF-SB）的形态缓解或改善方面的价值。当前版本中的一些变化包括更严格的红细胞输血依赖性和独立性定义，以及考虑将骨髓增生性肿瘤症状评估表作为量化疾病相关症状有意义变化的工具。列出了6种缓解类别：完全缓解（CR）和部分缓解表示与疾病改善一致的治疗效果，而药物诱导的MF-SB改善被注释为临床改善、贫血缓解、脾缓解或症状缓解。还提供了疾病进展、疾病稳定和复发的其他标准。该文件还包括评估细胞遗传学和分子缓解的建议，但不强制将其纳入CR分配。
The current document is a revision of the International Working Group-Myeloproliferative Neoplasms Research and Treatment (IWG-MRT) criteria for treatment response in myelofibrosis (MF) and represents a collaborative effort by the IWG-MRT and the European LeukemiaNet to objectively assess the value of new drugs in inducing morphologic remission or improvement in MF-associated symptomatic burden (MF-SB). Some of the changes in the current revision include stricter definitions of red cell transfusion dependency and independency and consideration of the Myeloproliferative Neoplasm Symptom Assessment Form as a tool to quantify meaningful changes in disease-related symptoms. Six response categories are listed: complete remission (CR) and partial remission signify treatment effects that are consistent with disease modification, whereas drug-induced improvements in MF-SB were annotated as clinical improvement, anemia response, spleen response, or symptoms response. Additional criteria are provided for progressive disease, stable disease, and relapse. The document also includes recommendations for assessing cytogenetic and molecular remissions, without mandating their inclusion for CR assignment.