Pulmonary Endothelial Cell Apoptosis in Emphysema and Acute Lung Injury.

Pulmonary Endothelial Cell Apoptosis in Emphysema and Acute Lung Injury.
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DOI:
10.1007/978-3-319-68483-3_4
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发表时间:
2018
期刊:
Advances in anatomy, embryology, and cell biology
影响因子:
--
通讯作者:
Lu Q
Lu Q
中科院分区:
其他
文献类型:
--
作者:
Chambers E;Rounds S;Lu Q

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细胞凋亡在人体内环境稳定和多种疾病的发病机制中起着重要作用。内皮细胞暴露于各种环境和内部应力,内皮细胞凋亡是这些刺激的病理生理后果。肺内皮细胞凋亡启动或促进许多肺部疾病的进展。本章将重点介绍目前对肺内皮细胞凋亡在肺气肿和急性肺损伤(ALI)发生发展中的作用以及控制肺内皮细胞生死的因素的认识。
Apoptosis plays an essential role in homeostasis and pathogenesis of a variety of human diseases. Endothelial cells are exposed to various environmental and internal stress and endothelial apoptosis is a pathophysiological consequence of these stimuli. Pulmonary endothelial cell apoptosis initiates or contributes to progression of a number of lung diseases. This chapter will focus on the current understanding of the role of pulmonary endothelial cell apoptosis in the development of emphysema and acute lung injury (ALI) and the factors controlling pulmonary endothelial life and death.
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