The Restless Brain
The Restless Brain
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DOI：
10.1089/brain.2011.0019
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发表时间：
2011-01-01
影响因子：
3.4
通讯作者：
Raichle, Marcus E.
中科院分区：
文献类型：
--
作者：
Raichle, Marcus E.
更好地了解人脑组织的迫切需要得到了所有努力解释人类健康和疾病行为独特性的人的理解。布罗德曼和其他人在人脑细胞建筑学方面的早期工作，以及几个世纪以来的病变行为工作，虽然很有价值，但远远达不到我们所需。幸运的是，在过去的40年里，现代脑成像技术已经极大地改变了这种情况，允许对活着的人脑内的解剖和功能关系进行安全评估。这项工作的一个意想不到的特点是正在进行的内在活动的关键重要性，它占大脑能量消耗的大部分，并显示出令人惊讶的组织水平，出现在空间和时间的维度上。在这篇文章中，我们回顾了内在活动的一些独特特征，因为它与我们对大脑组织的理解有关。
The pressing need to better understand human brain organization is appreciated by all who have labored to explain the uniqueness of human behavior in health and disease. Early work on the cytoarchitectonics of the human brain by Brodmann and others accompanied by several centuries of lesion behavior work, although valuable, has left us far short of what we need. Fortunately, modern brain imaging techniques have, over the past 40 years, substantially changed the situation by permitting the safe appraisal of both anatomical and functional relationships within the living human brain. An unexpected feature of this work is the critical importance of ongoing, intrinsic activity, which accounts for the majority of brain's energy consumption and exhibits a surprising level of organization that emerges with dimensions of both space and time. In this essay, some of the unique features of intrinsic activity are reviewed, as it relates to our understanding of brain organization.