Cytokine-producing dendritic cells in the pathogenesis of inflammatory skin diseases.
Cytokine-producing dendritic cells in the pathogenesis of inflammatory skin diseases.
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DOI：
10.1007/s10875-009-9278-8
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发表时间：
2009-05
影响因子：
9.1
通讯作者：
Lowes, Michelle A.
中科院分区：
文献类型：
--
作者：
Johnson-Huang, Leanne M.;McNutt, N. Scott;Krueger, James G.;Lowes, Michelle A.
炎症性皮肤病可以从多种角度进行检查。在这篇综述中，我们从主要病变树突状细胞（DC）亚群的角度考虑了三种不同的皮肤炎症性疾病。考虑的 DC 群体包括朗格汉斯细胞、髓样 DC 和浆细胞样 DC (pDC)，特别关注这些细胞的炎症对应物的存在和作用。从这样一个“以树突状细胞为中心”的焦点出发，对牛皮癣、特应性皮炎（AD）和皮肤红斑狼疮（CLE）进行了探索。在银屑病中，有一个特定的髓系“炎性”DC 群体似乎发挥着重要的致病作用，而 pDC 最近与银屑病病变的发生有关。在 AD 中，朗格汉斯细胞在起始过程中可能很重要，而“炎症树突状表皮细胞”(IDEC) 似乎在病变表皮和真皮中丰富，有助于 AD 的维持。这些 IDEC 实际上可能类似于牛皮癣皮肤表皮和真皮区室中发现的骨髓炎症 DC，尽管它们表达不同的表面标记，并由于它们发育的不同细胞因子环境而诱导不同的 T 细胞极性。 CLE 最近被定性为 I 型 IFN 介导的疾病，pDC 是该疾病发病机制中不可或缺的一部分。因此，将在这三种皮肤病的背景下对这些 DC 亚群及其产物进行审查，以提供病变 DC、其产物和皮肤病之间的临床病理生理学相关性。
Inflammatory skin diseases can be examined from many viewpoints. In this review, we consider three distinct cutaneous inflammatory diseases from the point of view of their major lesional dendritic cell (DC) subpopulations. The DC populations considered are Langerhans cells, myeloid DCs, and plasmacytoid DCs (pDCs), with specific attention to the presence and role of the inflammatory counterparts of these cells. From such a “dendritic cell-centric” focus, psoriasis, atopic dermatitis (AD), and cutaneous lupus erythematosus (CLE) are explored. In psoriasis, there is a specific population of myeloid “inflammatory” DCs that appears to play an important pathogenic role, while pDCs have been recently implicated in the initiation of psoriatic lesions. In AD, Langerhans cells may be important during initiation, while “inflammatory dendritic epidermal cells” (IDECs) appear to be abundant in lesional epidermis and dermis and contribute to maintenance of AD. These IDECs may actually be analogous to the myeloid inflammatory DCs found in the epidermal and dermal compartments of the skin in psoriasis, although they express distinct surface markers and induce different T cell polarities as a result of different cytokine milieu in which they develop. CLE has been recently characterized as a type I IFN-mediated disease, and pDCs are integral to the pathogenesis of this disease. Thus these DC subpopulations and their products will be reviewed in the context of these three cutaneous diseases, to provide clinico-pathophysiological correlations between the lesional DC, their products, and the skin diseases.
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影响因子：
30.5
作者：
Acosta-Rodriguez, Eva V.;Napolitani, Giorgio;Sallusto, Federica
通讯作者：
Sallusto, Federica
影响因子：
4.4
作者：
Ito, T;Amakawa, R;Fukuhara, S
通讯作者：
Fukuhara, S
影响因子：
56.9
作者：
Duerr, Richard H.;Taylor, Kent D.;Cho, Judy H.
通讯作者：
Cho, Judy H.
影响因子：
9.8
作者：
Cargill, Michele;Schrodi, Steven J.;Begovich, Ann B.
通讯作者：
Begovich, Ann B.
影响因子：
14.2
作者：
Ebner, Susanne;Nguyen, Van Anh;Romani, Nikolaus
通讯作者：
Romani, Nikolaus