The study of women, infant feeding and type 2 diabetes after GDM pregnancy and growth of their offspring (SWIFT Offspring study): prospective design, methodology and baseline characteristics.
The study of women, infant feeding and type 2 diabetes after GDM pregnancy and growth of their offspring (SWIFT Offspring study): prospective design, methodology and baseline characteristics.
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DOI：
10.1186/s12884-015-0587-z
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发表时间：
2015-07-17
影响因子：
3.1
通讯作者：
Quesenberry CP Jr
中科院分区：
文献类型：
--
作者：
Gunderson EP;Hurston SR;Dewey KG;Faith MS;Charvat-Aguilar N;Khoury VC;Nguyen VT;Quesenberry CP Jr
母乳喂养与降低日后超重或肥胖的风险有关。母乳喂养的婴儿在婴儿期比配方奶粉喂养的婴儿长得慢。在子宫内暴露于母体葡萄糖耐受不良的后代中，婴儿期生长的前瞻性数据尚未获得。因此，科学证据不足以得出结论，母乳喂养可以降低糖尿病母亲（ODM）后代患肥胖症的风险。为了解决这一差距，我们设计了GDM妊娠后妇女、婴儿喂养和2型糖尿病及其后代生长的研究，也称为SWIFT后代研究。这项前瞻性纵向研究从SWIFT研究中招募了母婴对，SWIFT研究是一项针对近期患有妊娠期糖尿病（GDM）的女性的前瞻性研究。SWIFT后代研究的目的是确定与配方奶粉喂养相比，母乳喂养强度和持续时间是否与GDM后代在第一年的生长较慢有关。本文详细介绍了研究设计，参与者资格，数据收集和方法。我们还描述了基线特征的GDM母婴对。该研究从2009年至2011年在北方加州的GDM分娩中招募了466对母婴。参与者在分娩后6-9周、6个月和12个月参加了三次亲自研究检查，以进行婴儿人体测量（头围、体重、身长、腹围和皮褶厚度）以及母亲人体测量（体重、腰围和体脂百分比）。母亲们还完成了关于健康和生活方式行为的问卷调查，包括婴儿的饮食、睡眠和气质。从出生到生命的第一年，通过几个来源（日记，电话采访，每月邮件和亲自检查）评估母乳喂养的强度和持续时间。从健康计划电子病历中获取妊娠过程、临床围产结局和新生儿结局。收集并储存婴儿唾液样本用于遗传学研究。这个庞大的，种族和民族多样化的GDM后代的队列将使婴儿喂养的关系，在婴儿期生长独立的围产期特征，社会人口统计学和其他危险因素的评估。纵向设计提供了第一个定量措施的母乳喂养强度和持续时间之间的GDM后代在生命早期。
Breastfeeding is associated with reduced risk of becoming overweight or obese later in life. Breastfed babies grow more slowly during infancy than formula-fed babies. Among offspring exposed in utero to maternal glucose intolerance, prospective data on growth during infancy have been unavailable. Thus, scientific evidence is insufficient to conclude that breastfeeding reduces the risk of obesity among the offspring of diabetic mothers (ODM). To address this gap, we devised the Study of Women, Infant Feeding and Type 2 Diabetes after GDM Pregnancy and Growth of their Offspring, also known as the SWIFT Offspring Study. This prospective, longitudinal study recruited mother-infant pairs from the SWIFT Study, a prospective study of women with recent gestational diabetes mellitus (GDM). The goal of the SWIFT Offspring Study is to determine whether breastfeeding intensity and duration, compared with formula feeding, are related to slower growth of GDM offspring during the first year life. This article details the study design, participant eligibility, data collection, and methodologies. We also describe the baseline characteristics of the GDM mother-infant pairs. The study enrolled 466 mother-infant pairs among GDM deliveries in northern California from 2009–2011. Participants attended three in-person study exams at 6–9 weeks, 6 months and 12 months after delivery for infant anthropometry (head circumference, body weight, length, abdominal circumference and skinfold thicknesses), as well as maternal anthropometry (body weight, waist circumference and percent body fat). Mothers also completed questionnaires on health and lifestyle behaviors, including infant diet, sleep and temperament. Breastfeeding intensity and duration were assessed via several sources (diaries, telephone interviews, monthly mailings and in-person exams) from birth through the first year of life. Pregnancy course, clinical perinatal and newborn outcomes were obtained from health plan electronic medical records. Infant saliva samples were collected and stored for genetics studies. This large, racially and ethnically diverse cohort of GDM offspring will enable evaluation of the relationship of infant feeding to growth during infancy independent of perinatal characteristics, sociodemographics and other risk factors. The longitudinal design provides the first quantitative measures of breastfeeding intensity and duration among GDM offspring during early life.