Alveolar cleft osteoplasty using tissue-engineered osteogenic material
Alveolar cleft osteoplasty using tissue-engineered osteogenic material
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DOI：
10.1016/j.ijom.2005.12.007
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发表时间：
2006-06-01
影响因子：
2.4
通讯作者：
Endo, Y
中科院分区：
文献类型：
--
作者：
Hibi, H;Yamada, Y;Endo, Y
组织工程化成骨材料包括富含血小板的血浆和分离、扩增并诱导为成骨潜能的自体骨髓间充质干细胞，作为自体骨移植的替代材料，可提供可预测的结果，且供区发病率最低。该材料被应用于一位9岁女性患者的牙槽裂成形术。术后3个月裂隙壁长出新生骨，6个月后裂隙桥接，9个月后当患侧尖牙和侧切牙在重建牙槽突处萌出时，移植区占79.1%。
The use of tissue-engineered osteogenic material comprising platelet-rich plasma and autologous mesenchymal stem cells isolated, expanded and induced to osteogenic potential in bone augmentation procedures as a replacement for autologous bone grafts, offers predictable results with minimal donor-site morbidity. This material was applied for an alveolar cleft osteoplasty of a 9-year-old female patient. Serial computed tomograms showed the regenerated bone extending from the cleft walls after 3 months and bridging the cleft after 6 months, with 79.1% of the grafted region after 9 months at the time when the canine and lateral incisor in the affected side erupted in the reconstructed alveolar ridge.