The continuing increase in adenocarcinoma of the uterine cervix: a birth cohort phenomenon.
The continuing increase in adenocarcinoma of the uterine cervix: a birth cohort phenomenon.
复制标题
子宫颈腺癌的持续增加：出生队列现象。
DOI：
10.1093/ije/25.2.252
复制
发表时间：
1996
影响因子：
7.7
通讯作者：
Boyle,P
中科院分区：
文献类型：
--
作者：
Zheng,T;Holford,TR;Ma,Z;Chen,Y;Liu,W;Ward,BA;Boyle,P
背景宫颈腺癌在年轻白色妇女中有增加的报道，早期的研究表明观察到的增加有出生队列模式。没有研究，但是，已经检查了子宫颈腺癌的出生cohol.MethodsUsing监测，流行病学和最终结果（SEER）的数据，通过1990年的时间趋势，目前的研究旨在检查浸润性腺癌的出生队列的时间趋势。一个年龄段队列模型拟合到每年的特定年龄的发病率，以确定组成部分的出生队列和时间penod作为所观察到的时间trends.ResultsThe结果从这项研究清楚地表明，浸润性腺癌的子宫颈一直在增加，在白人和黑人，但增加是统计学上显着的，只有在白人中，达到4.2%，每年为那些自1935年以来出生。结果还表明，最近的增加浸润性腺癌开始在那些出生在20世纪20年代中期左右，和强大的出生队列效应是主要负责观察increasing.ConclusionsInvasive adenocarcinoma的子宫颈是最近出生的队列之间增加。迫切需要进行分析性流行病学研究，以探讨造成这一增加的风险因素。在未来几年中，还应仔细监测宫颈腺癌的时间趋势。
BackgroundAdenocarcinoma of the uterine cervix has been reported to be increasing among young white women and earlier studies suggest a birth cohort pattern for the observed increase. No study, however, has examined the time trends of adenocarcinoma of the cervix by birth cohort.MethodsUsing Surveillance, Epidemiology, and End Results (SEER) data through 1990, the current study is designed to examine the time trends of invasive adenocarcinoma by birth cohort. An age-period-cohort model was fitted to the annual age-specific rates to identify the components of birth cohort and time penod as determinants of the observed time trends.ResultsThe results from this study clearly show that invasive adenocarcinoma of the uterine cervix has been increasing in both whites and blacks but the increase is statistically significant only among whites, reaching 4.2% per year for those born since 1935. The results also show that the recent increase in invasive adenocarcinoma started among those born around the mid 1920s, and a strong birth cohort effect is largely responsible for the observed increase.ConclusionsInvasive adenocarcinorna of the uterine cervix is increasing among recent birth cohorts. Analytical epidemiological studies are urgently needed to explore the risk factors responsible for the increase. The time trend for adenocarcinoma of the cervix should also be carefully monitored in the coming years.