Associative plasticity in the medial auditory thalamus and cerebellar interpositus nucleus during eyeblink conditioning.
Associative plasticity in the medial auditory thalamus and cerebellar interpositus nucleus during eyeblink conditioning.
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DOI：
10.1523/jneurosci.0208-10.2010
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发表时间：
2010-06-30
期刊：
影响因子：
--
通讯作者：
Freeman JH
中科院分区：
文献类型：
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作者：
Halverson HE;Lee I;Freeman JH
眨眼条件反射是一种联想运动学习，需要小脑。内侧听丘脑是听性眨眼条件反射过程中小脑必要的刺激输入来源。关于联想学习过程中丘脑和小脑之间的相互作用，目前还一无所知。在目前的研究中，在听觉眨眼条件反射过程中，同时记录了小脑间位核和内侧听觉丘脑的神经元活动，以检查这些相互连接的区域内与学习相关的可塑性的相对时间。在训练过程中和条件反射试验中，与眨眼条件反应相关的神经元活动的学习相关变化在内侧听觉丘脑之前的小脑中明显存在，这表明丘脑的可塑性可能是由小脑反馈驱动的。短潜伏期可塑性在第一次条件化训练中在丘脑发展，可能反映了对条件性刺激的注意。消退训练导致这两个结构中与学习相关的活动减少，小脑内的抑制增加。小脑核团向内侧听丘脑的反馈投射可能通过丘脑-桥脑投射促进刺激进入小脑，从而在学习中发挥作用。
Eyeblink conditioning, a type of associative motor learning, requires the cerebellum. The medial auditory thalamus is a necessary source of stimulus input to the cerebellum during auditory eyeblink conditioning. Nothing is currently known about interactions between the thalamus and cerebellum during associative learning. In the current study, neuronal activity was recorded in the cerebellar interpositus nucleus and medial auditory thalamus simultaneously from multiple tetrodes during auditory eyeblink conditioning to examine the relative timing of learning-related plasticity within these interconnected areas. Learning-related changes in neuronal activity correlated with the eyeblink conditioned response were evident in the cerebellum before the medial auditory thalamus over the course of training and within conditioning trials, suggesting that thalamic plasticity may be driven by cerebellar feedback. Short-latency plasticity developed in the thalamus during the first conditioning session and may reflect attention to the conditioned stimulus. Extinction training resulted in a decrease in learning-related activity in both structures and an increase in inhibition within the cerebellum. A feedback projection from the cerebellar nuclei to the medial auditory thalamus was identified, which may play a role in learning by facilitating stimulus input to the cerebellum via the thalamo-pontine projection.