Stratification of hepatocellular carcinoma risk in primary biliary cirrhosis: a multicentre international study
Stratification of hepatocellular carcinoma risk in primary biliary cirrhosis: a multicentre international study
复制标题
DOI：
10.1136/gutjnl-2014-308351
复制
发表时间：
2016-02-01
期刊：
影响因子：
24.5
通讯作者：
Hirschfield, Gideon M.
中科院分区：
文献类型：
--
作者：
Trivedi, Palak J.;Lammers, Willem J.;Hirschfield, Gideon M.
肝细胞癌（HCC）是原发性胆汁性肝硬化（PBC）中罕见但严重的事件，然而，预测工具仍然不明确。我们的目的是确定PBC患者发生HCC的候选危险因素。设计在北美和欧洲超过15个中心进行了风险因素分析，观察期超过40年，使用考克斯比例风险假设，逻辑回归和Kaplan-Meier估计。结果4565例PBC患者中，123例发生HCC，得出的发病率（IR）为3.4例/1000患者-年。HCC在男性中明显更常见（p
Objective Hepatocellular carcinoma (HCC) is an infrequent yet critical event in primary biliary cirrhosis (PBC); however, predictive tools remain ill-defined. Our objective was to identify candidate risk factors for HCC development in patients with PBC.Design Risk factor analysis was performed in over 15 centres from North America and Europe spanning >40 years observation period using Cox proportional hazards assumptions, logistic regression, and Kaplan-Meier estimates.Results Of 4565 patients with PBC 123 developed HCC, yielding an incidence rate (IR) of 3.4 cases/1000 patient-years. HCC was significantly more common in men (p