Use of a self-designed bladder controller for restoring bladder function in paraplegic dogs.
Use of a self-designed bladder controller for restoring bladder function in paraplegic dogs.
复制标题
使用自行设计的膀胱控制器恢复截瘫犬的膀胱功能。
DOI：
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发表时间：
2003
期刊：
影响因子：
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通讯作者：
Wei Zhang
中科院分区：
文献类型：
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作者：
Shi;C. Hou;Ying;Ai;Shimin Zhang;Bo Lei;Cheng;Wei Zhang
目的
目的评价自行设计的膀胱控制器对截瘫犬排尿功能的恢复效果。
方法
4只狗的脊髓在锥体上方横断。将电极植入双侧S2，并连接到皮下接收器进行外部激活。采用显微外科技术，硬膜内切断S1-3脊神经后根。每天刺激犬以观察排尿。进行尿动力学检查和膀胱造影。
结果
所有犬均在电刺激控制下获得排尿，每次尿量80-140 ml。排尿方式为刺激后排尿。膀胱造影显示电刺激排尿过程中膀胱充盈良好，膀胱颈开放。残余尿量为15-20 ml。尿动力学检查发现膀胱压力和尿道内压力同时升高，但当尿道内压力大于膀胱压力时，无排尿发生。在两次爆发之间，压力迅速下降至基线，膀胱压力缓慢下降。当膀胱压力大于尿道内压力时，发生排尿。
结论
自行设计的膀胱控制器结合骶神经传入阻滞术可恢复截瘫犬的排尿功能。
OBJECTIVE
To evaluate the results of a self-designed bladder controller for restoring micturition function in paraplegic dogs.
METHODS
The spinal cords of 4 dogs were transected above the cone. Electrodes were implanted in S2 bilaterally and connected to the subcutaneous receivers for external activation. Microsurgical technique was employed to perform dorsal rhizotomy of S1-3 intradurally. The dogs were stimulated daily to observe micturition. Urodynamic testing and vesicography were performed.
RESULTS
All the dogs acquired micturition under the control of electric stimulation, with urine volume 80-140 ml per time. The mode of micturition was post-stimulus voiding. Vesicography revealed that the bladder was filled well and the bladder neck was open in the micturition course of electric stimulation. Residual urine volume was 15-20 ml. Urodynamic testing found that the bladder pressure and intraurethral pressure increased simultaneously, but when the intraurethral pressure was greater than the bladder pressure, no micturition occurred. The pressure decreased to baseline rapidly and the bladder pressure decreased slowly between two bursts. Micturition occurred when the bladder pressure was greater than the intraurethral pressure.
CONCLUSIONS
The self-designed bladder controller together with a sacral deafferentation procedure can restore micturition function of paraplegic dogs.