Neuronal calcium-binding proteins and schizophrenia
Neuronal calcium-binding proteins and schizophrenia
复制标题
DOI：
10.1016/s0920-9964(01)00299-7
复制
发表时间：
2002-09-01
影响因子：
4.5
通讯作者：
Reynolds, GP
中科院分区：
文献类型：
--
作者：
Eyles, DW;McGrath, JJ;Reynolds, GP
钙结合蛋白(CBPS)，如钙结合蛋白、小白蛋白和钙视黄素，被用作离散神经元亚群的免疫组织化学标记。它们在识别GABA能中间神经元的不同亚群时特别有用，这些亚群控制着前额叶和扣带皮质以及海马区的输出。这些中间神经元在调节这三个关键脑区的输出方面发挥着战略作用，使它们成为精神分裂症神经病理学研究的重点。详细描述精神分裂症患者这些含CBP中间神经元的细微变化的病理报告的数量正在迅速增加。然而，这些蛋白质不仅仅是方便的神经元标记。它们赋予神经元生存优势，并能提高神经元维持放电的能力。这些特性可能在精神分裂症等非退行性现象的微妙病理生理学中很重要。这篇综述的目的是向读者介绍CBPS的功能特性，并审查有关精神分裂症患者这些蛋白变化的最新文献，并就这些发现的意义得出一些结论。(C)2002 Elsevier Science B.V.保留所有权利。
Calcium-binding proteins (CBPs) such as calbindin, parvalbumin and calretinin are used as immunohistochemical markers for discrete neuronal subpopulations. They are particularly useful in identifying the various subpopulations of GABAergic interneurons that control output from prefrontal and cingulate cortices as well as from the hippocampus. The strategic role these interneurons play in regulating output from these three crucial brain regions has made them a focus for neuropathological investigation in schizophrenia. The number of pathological reports detailing subtle changes in these CBP-containing interneurons in patients with schizophrenia is rapidly growing. These proteins however are more than convenient neuronal markers. They confer survival advantages to neurons and can increase the neuron's ability to sustain firing. These properties may be important in the subtle pathophysiology of nondegenerative phenomena such as schizophrenia. The aim of this review is to introduce the reader to the functional properties of CBPs and to examine the emerging literature reporting alterations in these proteins in schizophrenia as well as draw some conclusions about the significance of these findings. (C) 2002 Elsevier Science B.V. All rights reserved.