Short- and long-range attraction of cortical GABAergic interneurons by Neuregulin-1
Short- and long-range attraction of cortical GABAergic interneurons by Neuregulin-1
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DOI：
10.1016/j.neuron.2004.09.028
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发表时间：
2004-10-14
期刊：
影响因子：
16.2
通讯作者：
Marín, O
中科院分区：
文献类型：
--
作者：
Flames, N;Long, JE;Marín, O
大多数皮质中间神经元来自皮质下的端脑，但控制它们迁移的分子在很大程度上仍不清楚。在这里，我们显示了不同亚型的NeuRegin-1在发育中的皮质以及迁移的中间神经元向皮质的路径中表达，而一组迁移的中间神经元表达ErbB4，NeuRegin-1的受体。NeuRegin-1的不同亚型对迁移的中间神经元起着短期和长期的吸引作用，而在体外干扰ErbB4的功能会减少切向迁移到皮质的中间神经元的数量。在体内，NeuRegin-1/ErbB4信号的丢失导致皮质中间神经元切向迁移的改变和出生后皮质中GABA能中间神经元数量的减少。这些观察结果为NeuRegin-1及其ErbB4受体直接控制神经系统中的神经元迁移提供了证据。
Most cortical interneurons arise from the subcortical telencephalon, but the molecules that control their migration remain largely unidentified. Here, we show that different isoforms of Neuregulin-1 are expressed in the developing cortex and in the route that migrating interneurons follow toward the cortex, whereas a population of the migrating interneurons express ErbB4 a receptor for Neuregulin-1. The different isoforms of Neuregulin-1 act as short- and long-range attractants for migrating interneurons, and perturbing ErbB4 function in vitro decreases the number of interneurons that tangentially migrate to the cortex. In vivo, loss of Neuregulin-1/ErbB4 signaling causes an alteration in the tangential migration of cortical interneurons and a reduction in the number of GABAergic interneurons in the postnatal cortex. These observations provide evidence that Neuregulin-1 and its ErbB4 receptor directly control neuronal migration in the nervous system.