Osmotic Opening of the Blood-Brain Barrier in the Monkey without Associated Neurological Deficits
Osmotic Opening of the Blood-Brain Barrier in the Monkey without Associated Neurological Deficits
复制标题
猴子血脑屏障的渗透性开放，不伴有神经功能缺陷
作者：
S. Rapoport;H. K. Thompson
高渗尿素或乳酸盐溶液可主动打开猴的血脑屏障，如果大脑的血液供应未受损，则不会产生严重的神经功能缺损。当暂时夹闭颈外动脉和颈总动脉时，通过左舌动脉灌注脑。高渗灌注通过打开脑血管内皮细胞之间的紧密连接来打开屏障，因此可以用于研究屏障功能和脑药理学。
Hypertonic urea or lactamide solutions osmotically open the blood-brain barrier in the monkey without producing gross neurological deficits if the blood supply to the brain is not compromised. The brain is perfused via the left lingual artery when the external and common carotid arteries are clamped temporarily. Hypertonic perfusion, which opens the barrier by opening tight junctions between cerebrovascular endothelial cells, can thus be used to study barrier function and brain pharmacology.