Senso-Immunologic Prospects for Complex Regional Pain Syndrome Treatment.
Senso-Immunologic Prospects for Complex Regional Pain Syndrome Treatment.
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DOI：
10.3389/fimmu.2021.786511
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发表时间：
2021
影响因子：
7.3
通讯作者：
Sunagawa M
中科院分区：
文献类型：
--
作者：
Okumo T;Takayama Y;Maruyama K;Kato M;Sunagawa M
复杂性区域疼痛综合征（CRPS）是一种慢性疼痛综合征，发生在手术、创伤或缺血导致的组织损伤中。这种严重疼痛状况的临床特征包括受影响皮肤的发红和肿胀。有趣的是，最近有人提出，瞬时受体电位锚蛋白1（TRPA 1）参与慢性缺血后疼痛，CRPS模型。TRPA1是降钙素基因相关肽（CGRP）阳性初级伤害感受器中表达的非选择性阳离子通道，在缺血性疾病中高度活化，导致疼痛的产生。本文就TRPA1的研究历史及其在痛觉、炎症和CRPS中的作用作一综述。此外，骨萎缩也被认为是CRPS的特征性临床体征。CRPS患者的骨微结构改变被认为是通过增强破骨细胞分化和活化而加重骨吸收引起的。虽然TRPA1可能是CRPS患者疼痛治疗的靶点，但我们也在本文中讨论了这一矛盾的情况。伤害感受器激活通过从游离神经末梢分泌CGRP降低骨破坏的风险。因此，TRPA1抑制可能导致严重的骨萎缩。然而，由于CRPS中骨萎缩的病理机制尚不清楚，因此合适的治疗策略存在争议。因此，我们建议使用最近开发的概念：感觉免疫学，重点关注CRPS中观察到的骨转换异常的缓解。
Complex regional pain syndrome (CRPS) is a chronic pain syndrome that occurs in tissue injuries as the result of surgery, trauma, or ischemia. The clinical features of this severely painful condition include redness and swelling of the affected skin. Intriguingly, it was recently suggested that transient receptor potential ankyrin 1 (TRPA1) is involved in chronic post-ischemia pain, a CRPS model. TRPA1 is a non-selective cation channel expressed in calcitonin gene-related peptide (CGRP)-positive primary nociceptors that becomes highly activated in ischemic conditions, leading to the generation of pain. In this review, we summarize the history of TRPA1 and its involvement in pain sensation, inflammation, and CRPS. Furthermore, bone atrophy is also thought to be a characteristic clinical sign of CRPS. The altered bone microstructure of CRPS patients is thought to be caused by aggravated bone resorption via enhanced osteoclast differentiation and activation. Although TRPA1 could be a target for pain treatment in CRPS patients, we also discuss the paradoxical situation in this review. Nociceptor activation decreases the risk of bone destruction via CGRP secretion from free nerve endings. Thus, TRPA1 inhibition could cause severe bone atrophy. However, the suitable therapeutic strategy is controversial because the pathologic mechanisms of bone atrophy in CRPS are unclear. Therefore, we propose focusing on the remission of abnormal bone turnover observed in CRPS using a recently developed concept: senso-immunology.
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复杂区域疼痛综合征 I 型大鼠模型中脊髓背角的表达谱揭示了介导疼痛和神经炎症反应的潜在机制
影响因子：
9.3
作者：
Chen, Ruixiang;Yin, Chengyu;Liu, Boyi
通讯作者：
Liu, Boyi
影响因子：
2.8
作者：
Deer, Timothy R.;Pope, Jason E.;Mekhail, Nagy
通讯作者：
Mekhail, Nagy
DOI：
10.1523/jneurosci.5369-07.2008
发表时间：
2008-03-05
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Andersson DA;Gentry C;Moss S;Bevan S
通讯作者：
Bevan S
影响因子：
7.3
作者：
Aubdool AA;Kodji X;Abdul-Kader N;Heads R;Fernandes ES;Bevan S;Brain SD
通讯作者：
Brain SD
影响因子：
4
作者：
Coderre, Terence J.
通讯作者：
Coderre, Terence J.