INFLUENCE OF PLASMA ONCOTIC PRESSURE ON LUNG WATER ACCUMULATION AND GAS-EXCHANGE AFTER EXPERIMENTAL LUNG INJURY IN THE PIG
INFLUENCE OF PLASMA ONCOTIC PRESSURE ON LUNG WATER ACCUMULATION AND GAS-EXCHANGE AFTER EXPERIMENTAL LUNG INJURY IN THE PIG
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DOI：
10.1111/j.1399-6576.1981.tb01621.x
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发表时间：
1981-01-01
影响因子：
2.1
通讯作者：
JANERAS, L
中科院分区：
文献类型：
--
作者：
ZETTERSTROM, H;JAKOBSON, S;JANERAS, L
在18只麻醉和人工通气的猪中，静脉输注油酸以诱导肺损伤，其特征在于肺含水量增加、顺应性降低和通气/灌注障碍。稳定期后，1/2的动物（P组）进行重复血浆置换，使其血浆渗透压（POP）减半。其余动物流血的并重新输注流出的血液，作为对照组。在两组中，注意保持平均左心房压力尽可能恒定。在血浆分离和shamapheresis，有没有显着增加静脉混合（FIO 2 [吸气O2分数] 0.21和0.6）在任何一组。在研究结束时，P组的吸气末压、死腔/潮气量比和湿/干肺重量比（WW/DW）显著较高。静脉混合物和WW/DW与肺动脉压和计算的肺毛细血管压显著相关，但与POP或POP减去肺动脉闭塞压无关。血浆oncogene压力的降低可能会增加先前受伤的肺中的肺含水量，但这种额外的水积聚并不一定会损害肺中的氧合。
In 18 anesthetized and artificially ventilated pigs, oleic acid was infused i.v. to induce a lung injury characterized by increased lung water content, decreased compliance and a ventilation/perfusion disturbance. After a stabilizing period, 1/2 of the animals (group P) underwent repeated plasmapheresis, which halved their plasma oncotic pressure (POP). The rest of the animals were bled and re-transfused with the shed blood, thus serving as a control group. In both groups care was taken to keep the mean left atrial pressure as constant as possible. During plasmapheresis and shamapheresis, there was no significant increase in venous admixture (FIO2 [inspiratory O2 fraction] 0.21 and 0.6) in either of the groups. At the end of the study end-inspiratory pressure, dead space/tidal volume ratio and wet/dry lung weight ratio (WW/DW) were significantly higher in group P. Venous admixture and WW/DW correlated significantly with pulmonary arterial pressure and calculated pulmonary capillary pressure, but not with POP or POP minus pulmonary arterial occlusion pressure. Reduction of plasma oncotic pressure may increase the lung water content in previously injured lungs, but this extra water accumulation does not necessarily impair oxygenation in the lungs.