Elevated inflammatory laboratory parameters in spontaneous cervical artery dissection as compared to traumatic dissection - A retrospective case-control study
Elevated inflammatory laboratory parameters in spontaneous cervical artery dissection as compared to traumatic dissection - A retrospective case-control study
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DOI：
10.1007/s00415-006-0109-z
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发表时间：
2006-06-01
影响因子：
6
通讯作者：
Sander, D
中科院分区：
文献类型：
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作者：
Forster, K;Poppert, H;Sander, D
几项研究报告感染是颈动脉夹层（CAD）的可能风险因素。我们回顾性分析了CAD患者的几个炎症参数，目的是检测自发性（n = 25）和创伤性（n = 18）CAD之间的差异。在这个病例对照研究中，我们观察到白细胞绝对值显著较高，（10.3 vs 8.1 G/L; p = 0.02）以及白细胞增多频率升高（64% vs 28%; p = 0.02）和CRP升高与创伤相关性CAD患者相比，无创伤史（“自发性”CAD）的患者（60%对28%; p = 0.04）。由于炎症实验室参数升高与感染率升高无关，因此这些结果暗示急性炎症作为自发性CAD的致病因素的作用。炎症过程的原因和机制仍然未知。
Several studies have reported infection as a possible risk factor for cervical artery dissection (CAD). We retrospectively analyzed several inflammatory parameters of CAD patients with the aim of detecting differences between spontaneous (n = 25) and traumatic (n = 18) CAD. In this case-control study, we observed significantly higher absolute leucocyte values (10.3 versus 8.1 G/L; p = 0.02) as well as an elevated frequency of leucocytosis (64% versus 28%; p = 0.02) and elevated CRP (60% versus 28%; p = 0.04) in patients without a history of trauma ("spontaneous" CAD) compared with patients with traumarelated CAD. As the elevated inflammatory laboratory parameters were not associated with an elevated infection rate, these findings imply a role of an acute inflammation as a pathogenetic factor in spontaneous CAD. The cause and mechanism of the inflammatory process remain unknown.