Common dynamics of globin family proteins.
Common dynamics of globin family proteins.
复制标题
球蛋白家族蛋白质的常见动力学。
DOI：
10.1080/15216540701222914
复制
发表时间：
2007
期刊：
影响因子：
4.6
通讯作者：
Yonetani,Takashi
中科院分区：
文献类型：
--
作者：
Laberge,Monique;Yonetani,Takashi
The recently discovered new members of the globin family, neurogobin and cytoglobin, are the object of sustained structural and functional studies aimed at understanding their physiological role and elucidating the impact of their bis‐his heme hexacoordination. However, no studies have yet considered the dynamics of this protein family, an essential link between structure and function. In this communication, we present normal mode analysis results for neuroglobin, cytoglobin, hemoglobin and myoglobin to provide exploratory insights into globin characteristic motions. Our results show a clear correlation in the protein dynamics of this family. All four globins exhibit a high degree of correlated displacements involving residues in the C, E and F helices and link regions. They suggest that these motions play an important role in the reversible oxygen binding function of these proteins. Further, our results may help rationalize some functional features of the 6c‐globins in that they alone exhibit correlated displacements of the G‐helix region.
