The prevalence of polycystic ovaries in women with type 2 diabetes mellitus
The prevalence of polycystic ovaries in women with type 2 diabetes mellitus
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DOI：
10.1046/j.1365-2265.2000.00884.x
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发表时间：
2000-01-01
影响因子：
3.2
通讯作者：
Conway, GS
中科院分区：
文献类型：
--
作者：
Conn, JJ;Jacobs, HS;Conway, GS
目的 多囊卵巢综合征 (PCOS) 和 2 型糖尿病都是与胰岛素抵抗和代偿性高胰岛素血症相关的常见病症。之前的报告指出，糖耐量受损和糖尿病在患有多囊卵巢综合症的女性中很常见。在本报告中，我们介绍了相反研究的结果：患有 2 型糖尿病的绝经前妇女中多囊卵巢的患病率。 受试者受试者是从医院糖尿病诊所招募的。对计算机记录的检索确定了 49 名患有 2 型糖尿病的绝经前妇女正在接受单独饮食或口服降血糖药的治疗，其中 38 名 (76%) 患者同意接受研究。 设计一项记录临床、人口统计和人体测量数据的横断面研究。测量了空腹代谢参数、生殖内分泌特征和卵巢尺寸。结果 82% 的 2 型糖尿病女性超声显示患有多囊卵巢。在这些女性中，52% 有皮肤雄激素过多症和/或月经失调的临床证据。代谢和生殖参数之间的相关性与胰岛素对卵巢的刺激作用一致。 PCO 组和非 PCO 组之间的代谢特征没有显着差异。 结论 患有 2 型糖尿病的女性多囊卵巢的患病率高于普通人群。然而，并非所有因 2 型糖尿病而患有高胰岛素血症的女性都会出现 PCO，这表明仅高胰岛素血症不足以表达这种卵巢形态。
OBJECTIVE Polycystic ovary syndrome (PCOS) and type 2 diabetes mellitus are both common conditions associated with insulin resistance and compensatory hyperinsulinaemia. Previous reports have noted that impaired glucose tolerance and diabetes are common in women with PCOS. In this report we present the results of the converse study: the prevalence of polycystic ovaries in premenopausal women presenting with type 2 diabetes mellitus.SUBJECTS Subjects were recruited from a hospital Diabetes Clinic. A search of computerized records identified 49 premenopausal women with type 2 diabetes mellitus being treated with diet alone or oral hypoglycaemic agents of whom 38 (76%) patients agreed to be studied.DESIGN A cross-sectional study recording clinical, demographic and anthropometric data. Measurements of fasting metabolic parameters, reproductive endocrine profiles and ovarian dimensions were taken.RESULTS Eighty-two percent of women with type 2 diabetes mellitus had polycystic ovaries on ultrasound. Of these women, 52% had clinical evidence of cutaneous hyperandrogenism and/or menstrual disturbance. Correlations between metabolic and reproductive parameters were consistent with a stimulatory action of insulin on the ovary. There was no significant difference between the PCO and non-PCO groups with respect to metabolic profiles.CONCLUSIONS Women with type 2 diabetes mellitus have a higher prevalence of polycystic ovaries than that reported in the general population. Not all women with hyperinsulinaemia due to type 2 diabetes mellitus, however, develop PCO suggesting that hyperinsulinaemia alone is not sufficient for the expression of this ovarian morphology.