Bilateral, incidentally found adrenal tumours - results of observation of 1790 patients registered at a single endocrinological centre.
Bilateral, incidentally found adrenal tumours - results of observation of 1790 patients registered at a single endocrinological centre.
复制标题
DOI：
--
复制
发表时间：
2010
影响因子：
2.1
通讯作者：
A. Kasperlik-Załuska;J. Słowińska-Srzednicka;E. Rosłonowska;M. Kochman;W. Jeske;M. Otto;A. Cichocki-A.-Cichoc
中科院分区：
文献类型：
--
作者：
A. Kasperlik-Załuska;J. Słowińska-Srzednicka;E. Rosłonowska;M. Kochman;W. Jeske;M. Otto;A. Cichocki-A.-Cichoc
引言在过去的22年中，我们登记了1790例偶然发现的肾上腺肿瘤（AI，肾上腺偶发瘤）。其中351人发现双侧肿瘤。我们研究的目的是分析双侧肿瘤的特征并总结其治疗方法。材料与方法本组1790例患者中，女性1311例，男性479例，年龄11-87岁。双侧肾上腺肿瘤患者组包括258名女性和93名男性，年龄在25-83岁之间。激素调查和影像学检查进行搜索亚临床肾上腺功能亢进，并确定肿瘤的恶性潜力。结果69例患者因肿瘤或内分泌目的（主要是前库兴综合征）接受手术治疗。组织学检查结果包括恶性肿瘤：转移瘤- 9例，肾上腺癌- 7例，淋巴瘤- 5例;非恶性肿瘤：腺瘤- 24例，结节性增生- 14例，骨髓脂肪瘤- 4例，嗜铬细胞瘤- 4例。亚临床库欣综合征在结节性增生（40%）比腺瘤（30%）相对更常见。结论：在20%的双侧AI患者中推荐手术指征，最常见的是腺瘤、结节性增生和肿瘤病理，非恶性组预后良好。(Pol J Endocrinol 2010; 61（1）：69-73）。
INTRODUCTION During the last 22 years we registered 1790 patients with incidentally found adrenal tumours (AI, adrenal incidentalomas). In 351 of them, bilateral tumours were detected. The aim of our study was to analyze the character of bilateral tumours and summarize the methods of their management. MATERIAL AND METHODS In the whole group of 1790 patients, there were 1311 women and 479 men, aged 11-87 years. The group of patients with bilateral adrenal tumours included 258 women and 93 men, 25-83 years old. Hormonal investigations and imaging examinations were performed to search for subclinical adrenal hyperfunction and to define the malignant potential of the tumours. RESULTS Sixty-nine patients were treated by surgery for oncological or endocrinological purposes (mainly pre-Cushing's syndrome). Histological findings included malignant tumours: metastases - 9, adrenal cancer - 7, and lymphomas - 5; and non-malignant tumours: adenomas - 24, nodular hyperplasia - 14, myelolipomas - 4, and pheochromocytomas - 4. Subclinical Cushing's syndrome was relatively more frequent in nodular hyperplasia (40%) than in adenomas (30%). CONCLUSIONS Indications for surgery were recommended in 20% of patients with bilateral AI, most frequently for adenomas, nodular hyperplasia, and oncological pathologies, with a good prognosis in the non-malignant group. (Pol J Endocrinol 2010; 61 (1): 69-73).