Thyroid hormones modulate serum leptin levels: observations in thyrotoxic and hypothyroid women.
Thyroid hormones modulate serum leptin levels: observations in thyrotoxic and hypothyroid women.
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DOI：
10.1089/thy.1998.8.1081
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发表时间：
1998-12
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影响因子：
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通讯作者：
M. Diekman;J. Romijn;E. Endert;H. Sauerwein;W. Wiersinga
中科院分区：
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作者：
M. Diekman;J. Romijn;E. Endert;H. Sauerwein;W. Wiersinga
甲状腺激素和瘦素都参与能量代谢的调节。血清瘦素浓度测定甲状腺毒症（n = 21，平均年龄45岁）或甲状腺功能减退症（n = 14，平均年龄44岁）的妇女甲状腺功能正常状态恢复前和3个月后。治疗后甲状腺功能减退（14.7+/-3.5 vs 17.8+/-3.9 ng/ml，p = 0.06）和甲状腺功能亢进（11.9+/-1.7 vs 14.4+/-2.0，p = 0.08）的妇女血清瘦素浓度有增加的趋势（未治疗和甲状腺功能正常状态下的值分别为平均值+/- SE）。甲状腺功能亢进妇女的体重指数（BMI）低于未治疗状态下甲状腺功能减退妇女（22.1+/-0.7 vs. 26.2+/-1.9，p < 0.05）。治疗后两组的BMI没有差异（24.5+/-0.7 vs. 26.3+/-2.1，p = 0.37），因为甲状腺功能亢进女性的BMI增加;甲状腺功能减退组的BMI没有变化。在多变量回归分析中，控制BMI后，甲状腺功能减退妇女的血清瘦素浓度低于甲状腺功能亢进妇女（p < 0.05），而治疗后瘦素值无差异（p = 0.44）。当瘦素浓度用与先前报道的BMI和年龄相匹配的女性对照组的平均值的标准差分数（Z分数）表示时，甲状腺功能减退的女性的Z分数低于甲状腺功能亢进的女性（-0.63+/-0.21 vs. 0.53+/-0.18，p = 0.001）。治疗后，Z评分未偏离预期值（0.05+/-0.28 vs. 0.08+/-0.16，p = 0.98）。甲状腺功能减退（p = 0.01）和甲状腺功能亢进（p = 0.02）患者治疗前后的Z评分不同。总之，这些数据在甲状腺功能亢进和甲状腺功能减退的妇女表明，甲状腺状态调节血清瘦素浓度独立的BMI，甲状腺功能减退症和甲状腺毒症的一个小的减少和一个小的增加。
Thyroid hormones and leptin are both involved in the regulation of energy metabolism. Serum leptin concentrations were measured in women with thyrotoxicosis (n = 21, mean age 45 years) or hypothyroidism (n = 14, mean age 44 years) before and 3 months after restoration of the euthyroid state. Serum leptin concentration tended to increase in both hypothyroid (14.7+/-3.5 vs 17.8+/-3.9 ng/ml, p = 0.06) and thyrotoxic (11.9+/-1.7 vs 14.4+/-2.0, p = 0.08) women after treatment (values given as mean +/- SE in the untreated and the euthyroid state respectively). Body mass index (BMI) was lower in thyrotoxic women than in hypothyroid women in the untreated state (22.1+/-0.7 vs. 26.2+/-1.9, p < 0.05). BMI was not different between both groups after treatment (24.5+/-0.7 vs. 26.3+/-2.1, p = 0.37), due to an increase of BMI in the thyrotoxic women; BMI did not change in the hypothyroid group. After controlling for BMI in a multivariate regression analysis, serum leptin concentrations were lower in hypothyroid women than in thyrotoxic women (p < 0.05), whereas posttreatment values of leptin did not differ (p = 0.44). When leptin concentrations were expressed as standard deviation scores (Z-scores) from the mean value of female controls matched for BMI and age as reported earlier, Z-scores were lower in the hypothyroid than in the thyrotoxic women (-0.63+/-0.21 vs. 0.53+/-0.18, p = 0.001). After treatment, Z-scores did not deviate from the expected values (0.05+/-0.28 vs. 0.08+/-0.16, p = 0.98). Z-scores differed before and after treatment in both hypothyroid (p = 0.01) and thyrotoxic (p = 0.02) patients. In conclusion, these data obtained in thyrotoxic and hypothyroid women indicate that thyroid states modulates serum leptin concentrations independent of BMI, with a small decrease in hypothyroidism and a small increase in thyrotoxicosis.