Role of chemokines in the regulation of Th1/Th2 and autoimmune encephalomyelitis
Role of chemokines in the regulation of Th1/Th2 and autoimmune encephalomyelitis
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DOI：
10.1023/a:1020535423465
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发表时间：
1999-09-01
影响因子：
9.1
通讯作者：
Karpus, WJ
中科院分区：
文献类型：
--
作者：
Kennedy, KJ;Karpus, WJ
趋化因子是低分子量的趋化肽，其结合七种跨膜G蛋白偶联受体并递送导致T细胞共刺激、造血、细胞因子表达、T细胞分化和整联蛋白活化的信号。实验性自身免疫性脑脊髓炎（EAE）是一种由CD4（+）Th1介导的中枢神经系统（CNS）脱髓鞘疾病，可作为多发性硬化症（MS）的模型。这种CNS脱髓鞘疾病的发病机制的标志是T细胞和单核细胞从血液迁移到CNS。有几个考虑因素表明趋化因子在炎性细胞流入和所产生的疾病过程中的作用，包括与疾病活动相关的紧密的时间表达模式和通过免疫抑制预防疾病发展。体内中和我们回顾的证据表明，时间和空间的表达趋化因子是至关重要的因素，补充粘附分子上调，调节EAE和潜在的MS疾病的活动，以及在Th1和Th2生物学的趋化因子的功能。
Chemokines are low molecular weight chemotactic peptides that bind seven transmembrane-spanning, G protein-coupled receptors and deliver signals leading to T cell costimulation, hematopoeisis, cytokine expression, T cell differentiation, and integrin activation. Experimental autoimmune encephalomyelitis (EAE) is a CD4(+) Th1-mediated demyelinating disease of the central nervous system (CNS) that serves as a model for multiple sclerosis (MS). A hallmark in the pathogenesis of this CNS demyelinating disease is the emigration of T cells and monocytes from the blood to the CNS. There are several considerations that suggest a role for chemokines in the influx of inflammatory cells and the resulting disease process including a tight temporal expression pattern with relationship to disease activity and prevention of disease development by in. vivo neutralization. We review the evidence that temporal and spatial expressions of chemokines are crucial factors, complementing adhesion molecule upregulation, that regulate EAE and potentially MS disease activity as well as the functions of chemokines in Th1 and Th2 biology.