Prognostic Implications of Arginase and Cytokeratin 19 Expression in Hepatocellular Carcinoma After Curative Hepatectomy: Correlation With Recurrence-Free Survival
Prognostic Implications of Arginase and Cytokeratin 19 Expression in Hepatocellular Carcinoma After Curative Hepatectomy: Correlation With Recurrence-Free Survival
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DOI：
10.14740/gr1156
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发表时间：
2019-04-01
影响因子：
1.5
通讯作者：
Kallakury, Bhaskar
中科院分区：
文献类型：
--
作者：
Obiorah, Ifeyinwa Emmanuela;Chahine, Oeffrey;Kallakury, Bhaskar
背景：精氨酸酶表达在肝细胞癌中的预后价值已被评估。然而，精氨酸酶-1作为肝细胞癌复发预测因子的作用还没有明确的区别。细胞角蛋白19(CK19)是一种胆管细胞标志物，在肝细胞癌中偶有表达，但精氨酸酶-1和CK19的联合表达从未被评估过。本研究的目的是探讨精氨酸酶-1和CK19单独和联合表达对预测肝癌手术后复发的价值。方法：对112例肝细胞癌组织切片进行免疫组织化学染色，用小鼠精氨酸酶-1和小鼠单抗CK19。临床病理变量包括甲胎蛋白水平、病毒性肝炎、肝硬变、肿瘤大小、分级和数目、血管侵犯、肿瘤淋巴结转移(TNM)分期、肿瘤复发和生存。评估变量与免疫化学结果的相关性。采用单变量和多变量回归分析进行无复发生存率和总生存率的比较。A的P值为
Background: The prognostic value of arginase expression in hepatocellular carcinoma (HCC) has been evaluated previously. However, no clear distinction exists yet on the role of arginase-1 as a predictor of recurrence in HCC. Cytokeratin 19 (CK19), a cholangiocytic marker, is occasionally expressed in HCC, but the combination of arginase-1 and CK19 expression has never been evaluated. The aim of the study was to investigate the usefulness of arginase-1 and CK19 expression alone and in combination for prognosticating HCC tumor recurrence after surgical resection.Methods: Tissue sections from 112 HCCs were immunostained using an automated method and the mouse monoclonal arginase-1 and mouse monoclonal CK19 antibodies. The clinicopathologic variables, including alpha-fetoprotein levels, viral hepatitis, cirrhosis, tumor size, grade and number, vascular invasion, tumor-node-metastasis (TNM) stage, and tumor recurrence and survival, were obtained from each patient's medical records. The variables were assessed for correlation with the immunochemical results. Comparisons of recurrence-free and overall survival were performed using univariate and multivariate regression analyses. A P-value of