The -308G/A polymorphism of the tumor necrosis factor-alpha gene is associated with the risk of upper aerodigestive tract cancer: a meta-analysis.
The -308G/A polymorphism of the tumor necrosis factor-alpha gene is associated with the risk of upper aerodigestive tract cancer: a meta-analysis.
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肿瘤坏死因子-α 基因的 -308G/A 多态性与上呼吸消化道癌症的风险相关：一项荟萃分析。
DOI：
10.1620/tjem.229.245
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Qianming Chen
中科院分区：
文献类型：
--
作者：
Jiayi Wang;Xin Jin;Hui Wang;Jiantang Yang;Li;Lei Lei;Xiaoxu Li;Yu Zhou;X. Zeng;Lu Jiang;Ga Liao;H. Dan;Qianming Chen
肿瘤坏死因子-α（TNF-α）已被认为有助于上呼吸消化道（UADT）癌症的发展，其特征是预后不良。TNF-α基因-308G/A多态性（-308G/A多态性）可增加TNF-α的表达水平，从而影响UADT癌的遗传易感性。-308G/A多态性与UADT癌症之间的关联已被广泛研究，但已发表的结果相当有争议。为了获得更准确的结论，我们进行了一项荟萃分析，包括1，751名患者和3，345名对照。结果表明，与G携带者（GG和GA基因型）相比，-308G/A基因AA型患UADT癌的风险增加54%[OR = 1.54，95%可信区间（CI）：1.07-2.21]。按种族分层后，AA基因型与南亚人UADT癌症风险增加相关（AA vs. GA+GG的OR = 33.18和95%CI：1.92-573.62），但与高加索人或东亚人无关。按肿瘤部位分层后，-308G/A多态性与口咽癌风险增加相关（AA与GA+GG的OR = 2.68和95%CI：1.34-5.35），但与食管癌和喉癌无关。按组织学类型分层后，-308G/A多态性与鳞状细胞癌的风险增加相关（AA与GA+GG的OR = 1.81和95%CI：1.15-2.84），但与腺癌无关。我们的研究结果表明，-308G/A多态性可能有助于UADT癌症易感性的风险增加。
Tumor necrosis factor-alpha (TNF-α) has been proposed to contribute to the development of upper aerodigestive tract (UADT) cancer that is characterized by poor prognosis. The G-to-A nucleotide change at -308 of the TNF-α gene (-308G/A polymorphism) can increase the expression level of TNF-α and thus may affect the genetic susceptibility of UADT cancer. The association between the -308G/A polymorphism and UADT cancer has been widely studied, but the results published are quite controversial. To obtain a more precise conclusion, we performed a meta-analysis including 1,751 patients and 3,345 controls. The results indicated that the AA genotype of the -308G/A polymorphism had a 54%-increased risk of UADT cancer, compared with the G carriers (GG and GA genotypes) [odds ratio (OR) = 1.54, 95% confidence interval (CI): 1.07-2.21]. After stratified by ethnicity, the AA genotype was associated with increased risk of UADT cancers in South Asians (OR = 33.18 and 95% CI: 1.92-573.62 for AA vs. GA+GG) but not in Caucasians or East Asians. After stratified by tumor site, the -308G/A polymorphism was associated with increased risks of oropharynx cancer (OR = 2.68 and 95% CI: 1.34-5.35 for AA vs. GA+GG) but not associated with esophagus or larynx cancer. After stratified by histological type, the -308G/A polymorphism was associated with increased risks of squamous cell carcinoma (OR = 1.81 and 95% CI: 1.15-2.84 for AA vs. GA+GG) but not associated with adenocarcinoma. Our results indicate that the -308G/A polymorphism might contribute to an increased risk of UADT cancer susceptibility.
影响因子：
9.8
作者：
Frisse, L;Hudson, RR;Di Rienzo, A
通讯作者：
Di Rienzo, A
影响因子：
20.3
作者：
Xu, Jun;Chakrabarti, Ayan K.;Vujanovic, Nikola L.
通讯作者：
Vujanovic, Nikola L.