Vaccines against veterinary helminths
Vaccines against veterinary helminths
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DOI：
10.1016/j.vetpar.2005.07.006
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发表时间：
2005-09-30
影响因子：
2.6
通讯作者：
Harrison, GBL
中科院分区：
文献类型：
--
作者：
Hein, WR;Harrison, GBL
大多数为兽医蠕虫开发商业疫苗的尝试都集中在鉴定蛋白质抗原上，这些抗原可以被配制成保护性疫苗。在一些寄生虫方面已经取得了显著的成功，重组蛋白已被开发成非常有效的疫苗。虽然利用一些原生形式的线虫蛋白也可以获得有效的保护，但还不可能为其他具有兽医意义的蠕虫寄生虫研制出商业上成功的疫苗。越来越多的证据表明，寄生虫聚糖部分可能提供疫苗抗原的另一种来源，目前这类化合物正受到越来越多的关注。除了确定候选保护性抗原外，还需要加强研究工作，以制定适当的策略来配制和提供蠕虫疫苗。(c) 2005 Elsevier B.V.版权所有
The majority of attempts to develop commercial vaccines for veterinary helminths have focussed on identifying protein antigens, which could be formulated as protective vaccines. Notable successes have been achieved for some cestode parasites, where recombinant proteins have been developed into highly effective vaccines. Although effective protection can also be obtained using some nematode proteins in their native forms, it has not yet been possible to formulate commercially successful vaccines for other helminth parasites of veterinary significance. Increasing evidence suggests that parasite glycan moieties may provide an alternative source of vaccine antigens, and increased attention is now being given to this class of compounds. In addition to identifying candidate protective antigen(s), an increased research effort is needed to develop appropriate strategies for the formulation and delivery of helminth vaccines. (c) 2005 Elsevier B.V. All rights reserved.