NK cell-mediated immune response against cancer
NK cell-mediated immune response against cancer
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DOI：
10.1016/j.suronc.2007.10.043
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发表时间：
2007-12-01
影响因子：
2.3
通讯作者：
Moretta, Lorenzo
中科院分区：
文献类型：
--
作者：
Moretta, Lorenzo
在过去的15年里，我们对自然杀伤（NK）细胞的功能、它们在先天防御中的作用以及它们在治疗中的可能利用的理解取得了巨大进展。这一贡献追溯了这些以前神秘的细胞的主要进展，从HLA I类特异性抑制受体的首次发现到最近的重大突破，突出了关于治愈危及生命的白血病的重要观点和主要期望。“同种异体反应性”NK细胞在根除急性髓性白血病和预防移植物排斥反应和移植物抗宿主病方面的关键作用，导致了骨髓移植的真正革命。因此，现在有可能寻找适当的HLA I类错配，以使NK细胞发挥作用，治愈高危白血病。(c)2007爱思唯尔有限公司版权所有。
The past fifteen years have witnessed great progress in our undestanding of how natural killer (NK) cells function, their role in innate defenses and their possibile exploitation in therapy. This contribution traces the major advances in these formerly mysterious cells, from the first discovery of HLA-class I-specific inhibitory receptors to a more recent major breakgthrough that highlighted important perspectives and major expectations regarding the cure of life-threatening leukemias. The key role of "alloreactive" NK cells in eradicating acute myeloid leukemias and in preventing both graft rejection and graft-versus-host disease, led to a true revolution in bone marrow transplantation. Thus, it is now possible to search for appropriate HLA class I mismatches to set NK cells in action to cure high risk leukemias. (c) 2007 Elsevier Ltd. All rights reserved.