α-glucosyl hesperidin suppressed the exacerbation of 5-fluorouracil-induced oral mucositis in the hamster cheek pouch.
α-glucosyl hesperidin suppressed the exacerbation of 5-fluorouracil-induced oral mucositis in the hamster cheek pouch.
复制标题
α-葡萄糖基橙皮苷抑制仓鼠颊囊中 5-氟尿嘧啶引起的口腔粘膜炎的恶化。
DOI：
10.1016/j.jff.2015.12.008
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发表时间：
2016
影响因子：
5.6
通讯作者：
Takahashi S-S
中科院分区：
文献类型：
--
作者：
Yoshino F;Yoshida A;Toyama T;Wada-Takahashi S;Takahashi S-S
橙皮苷（Hesperidin，Hsp）是柑橘类水果中含量丰富的黄酮类化合物，具有抗氧化、抗炎、抗癌等多种生物学功能。然而，热休克蛋白在水溶液中不能充分溶解，并且不能很好地通过肠道吸收。α-葡萄糖基橙皮苷（Hsp-G）是Hsp的衍生物，具有增强的水溶性，同时保留了Hsp的天然生物学功能。本研究旨在探讨Hsp-G在口腔黏膜炎中的生物学作用。Hsp-G具有清除羟自由基和超氧阴离子自由基的活性。口腔黏膜炎的面积显着小于仓鼠Hsp-G管理比非管理组。硫代巴比妥酸反应性物质的增加，表示为丙二醛当量，水平显着抑制了5-氟尿嘧啶给药前的热休克蛋白-G的预处理。Hsp-G对人口腔鳞癌细胞的抗肿瘤活性无影响。因此，Hsp-G可能作为一种功能性食品成分，以改善口腔黏膜炎的症状。
Hesperidin (Hsp), the so-called vitamin P, is an abundant flavonoid in citrus fruits and exerts many biological functions, including antioxidative, anti-inflammatory and anticarcinogenic activities. However, Hsp is not adequately soluble in aqueous solutions and not absorbed well through the intestinal tract. α-glucosyl hesperidin (Hsp-G) is a derivative of Hsp with enhanced water-solubility, while it retains the natural biological functions of Hsp. In this study, the biological functions of Hsp-G on oral stomatitis were examined. Hsp-G exhibited scavenging activity towards hydroxyl radical and superoxide anion radical. Oral stomatitis areas were significantly smaller in hamsters administered Hsp-G than in the non-administered group. Increases in thiobarbituric acid reactive substances, expressed as malondialdehyde equivalents, levels were significantly inhibited by the pre-treatment with Hsp-G prior to the administration of 5-fluorouracil. Hsp-G had no effect on anti-tumour activity in human oral squamous carcinoma cells. Therefore, Hsp-G may serve as a functional food ingredient to ameliorate the symptoms of oral stomatitis.