Cytokinesis: Robust cell shape regulation.
Cytokinesis: Robust cell shape regulation.
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DOI：
10.1016/j.semcdb.2015.10.023
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发表时间：
2016-05
影响因子：
7.3
通讯作者：
Robinson DN
中科院分区：
文献类型：
--
作者：
Srivastava V;Iglesias PA;Robinson DN
胞质分裂是细胞分裂的最后一步，是细胞形状调节的一个很好的例子。从单细胞网骨藻到组织中的人类细胞，各种各样的细胞在细胞分裂期间通过高度相似的、刻板的细胞形状变化进行。通常，细胞首先在中间形成分裂沟，其收缩导致两个子细胞的形成。细胞质分裂的严格控制对于遗传和细胞物质的适当分离是必不可少的，并且其失败对细胞活力是有害的。因此，生物系统已经开发出复杂的机制来确保细胞质分裂的高保真度，包括存在通过反馈调节的多种生化和机械途径。在这篇综述中，我们专注于内置的冗余的细胞骨架机器，使细胞分裂成功地在各种生物和机械环境。使用Dictyosteoblasts胞质分裂为例，我们表明，通过反馈的生化和机械信号之间的串扰，确保正确的组装和功能的细胞分裂机器。
Cytokinesis, the final step of cell division, is a great example of robust cell shape regulation. A wide variety of cells ranging from the unicellular Dictyostelium to human cells in tissues proceed through highly similar, stereotypical cell shape changes during cell division. Typically, cells first round up forming a cleavage furrow in the middle, which constricts resulting in the formation of two daughter cells. Tight control of cytokinesis is essential for proper segregation of genetic and cellular materials, and its failure is deleterious to cell viability. Thus, biological systems have developed elaborate mechanisms to ensure high fidelity of cytokinesis, including the existence of multiple biochemical and mechanical pathways regulated through feedback. In this review, we focus on the built-in redundancy of the cytoskeletal machinery that allows cells to divide successfully in a variety of biological and mechanical contexts. Using Dictyostelium cytokinesis as an example, we demonstrate that the crosstalk between biochemical and mechanical signaling through feedback ensures correct assembly and function of the cell division machinery.