Characteristics of white matter alterations along fibres in patients with bulimia nervosa: A combined voxelwise and tractography study
Characteristics of white matter alterations along fibres in patients with bulimia nervosa: A combined voxelwise and tractography study
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DOI：
10.1111/ejn.16077
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发表时间：
2023-07-09
影响因子：
3.4
通讯作者：
Wang，Zhenchang
中科院分区：
文献类型：
--
作者：
Chen，Qian;Wang，Miao;Wang，Zhenchang
越来越多的证据支持白质(WM)异常参与神经性暴食症(BN)病理生理的假说；然而，活体神经影像研究的结果并不一致。我们的目的是调查BN患者可能的脑白质改变，包括白质体积和微结构。我们招募了43名BN患者和31名健康对照(HCS)。所有参与者都接受了结构张量和扩散张量成像。使用基于体素的形态计量学、基于纤维束的空间统计学和自动纤维定量分析来评估WM体积和微观结构的差异。与HCS患者相比，BN患者的右侧脑神经V(CNV)(节点27-33和节点55-88)和枕纵束(VOF)(节点58-85)的各向异性分数显著降低(31~32个节点)，平均弥散率增加。此外，我们还发现右额枕下束(节点67)的轴向弥散系数降低，而在中央静脉(节点22-34和节点52-89)和左侧VOF(节点60-66和节点81-85)的径向弥散系数增加。同时，WM的微结构改变与患者的临床表现相关。我们没有发现BN患者和HCS患者在WM体积和主要WM纤维束属性上有任何显著差异。综上所述，这些发现表明，BN显示了显著的脑WM重组，但主要是在微观结构(WM纤维束的一部分)，这不足以引起WM体积的变化。自动纤维定量分析可以更灵敏地检测WM纤维束的一个点或段的细微病理变化。
Accumulating evidence supports the hypothesis that white matter (WM) abnormalities are involved in the pathophysiology of bulimia nervosa (BN); however, findings from in vivo neuroimaging studies have been inconsistent. We aimed to investigate the possible brain WM alterations, including WM volume and microstructure, in patients with BN. We recruited 43 BN patients and 31 healthy controls (HCs). All participants underwent structural and diffusion tensor imaging. Differences in WM volume and microstructure were evaluated using voxel‐based morphometry, tract‐based spatial statistics, and automated fibre quantification analysis. Compared with HCs, BN patients showed significantly decreased fractional anisotropy in the middle part of the corpus callosum (nodes 31–32) and increased mean diffusivity in the right cranial nerve V (CN V) (nodes 27–33 and nodes 55–88) and vertical occipital fasciculus (VOF) (nodes 58–85). Moreover, we found decreased axial diffusivity in the right inferior fronto‐occipital fasciculus (node 67) and increased radial diffusivity in the CN V (nodes 22–34 and nodes 52–89) and left VOF (nodes 60–66 and nodes 81–85). Meanwhile, WM microstructural changes were correlated with patients' clinical manifestations. We did not find any significant differences in WM volume and the main WM fibre bundle properties between BN patients and HCs. Taken together, these findings provide that BN shows significant brain WM reorganization, but primarily in microstructure (part of WM fibre bundle), which is not sufficient to cause changes in WM volume. The automated fibre quantification analysis could be more sensitive to detect the subtle pathological changes in a point or segment of the WM fibre bundle.