Association Between BDNF Val66Met Polymorphism and Alzheimer Disease, Dementia With Lewy Bodies, and Pick Disease
Association Between BDNF Val66Met Polymorphism and Alzheimer Disease, Dementia With Lewy Bodies, and Pick Disease
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DOI：
10.1097/wad.0b013e318199dd7d
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发表时间：
2009-07-01
影响因子：
2.1
通讯作者：
Janka, Zoltan
中科院分区：
文献类型：
--
作者：
Feher, Agnes;Anna Juhasz;Janka, Zoltan
脑源性神经营养因子（brain-derived neurotrophic factor，BDNF Va 166 Met）的功能多态性影响记忆相关的海马活动。载脂蛋白E（ApoE）基因多态性与阿尔茨海默病（AD）、路易体痴呆（DLB）和皮克病（PiD）相关。我们检验了BDNF瓦尔和ApoE β 4等位基因赋予AD、DLB和PiD易感性的假设。该研究包括160名AD，34名DLB患者，38名尸检证实的PiD和164名年龄匹配的健康对照（HC）先证者。AD组BDNF瓦尔等位基因频率显著高于HC组，而PiD组和DLB组与HC组相比无统计学差异。PiD中瓦尔/Met基因型的出现频率在统计学上显着高于HC。与HC相比，所有痴呆患者中ApoE ε 4等位基因的比例显著偏高。在所有研究的痴呆中，含有ApoE β 4和BDNF瓦尔等位基因的基因型比HC更常见。我们认为BDNF瓦尔等位基因本身以及与ApoE β 4等位基因的结合可能是AD的危险因素，结果表明2种多态性对DLB和PiD风险具有协同作用。
A functional polymorphism of the brain-derived neurotrophic factor (BDNF Va166Met) has been reported to affect memory-related hippocampal activity. Apolipoprotein E (ApoE) gene polymorphism is known to be associated with Alzheimer disease (AD), dementia with Lewy bodies (DLB), and Pick disease (PiD). We tested the hypothesis that BDNF Val and ApoE epsilon 4 alleles confer susceptibility to AD, DLB, and PiD. The study included 160 AD, 34 DLB patients, 38 autopsy-confirmed PiD, and 164 age-matched healthy control (HC) probands. The frequency of the BDNF Val allele was significantly higher in AD, but there were no statistical differences in the allele distribution in PiD or in DLB as compared with HC. The Val/Met genotype occurred with statistically significantly higher frequency in PiD than in HC. The ApoE epsilon 4 allele was significantly overrepresented in all dementias as compared with HC. Genotypes containing both ApoE epsilon 4 and BDNF Val alleles occurred more frequently in all investigated dementias than in HC. We suggest that the presence of the BDNF Val allele in itself and in combination with the ApoE epsilon 4 allele can be risk factors for AD, and the results indicate a synergistic effect of the 2 polymorphisms on DLB and PiD risk.