Yet another numbering scheme for immunoglobulin variable domains:: An automatic modeling and analysis tool
Yet another numbering scheme for immunoglobulin variable domains:: An automatic modeling and analysis tool
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DOI：
10.1006/jmbi.2001.4662
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发表时间：
2001-06-08
影响因子：
5.6
通讯作者：
Plückthun, A
中科院分区：
文献类型：
--
作者：
Honegger, A;Plückthun, A
已经设计了所有免疫球蛋白可变结构域（免疫球蛋白轻链 lambda (V-lambda) 和 kappa (V-kappa) 可变结构域、重链可变结构域 (V-H) 和 T 细胞受体 α (V-alpha)、β (V-beta)、gamma (V-gamma) 和 delta (V-delta) 可变结构域）的通用残基编号方案。基于免疫球蛋白结构域的已知三维结构的空间对齐，它以最小化与对齐结构域的平均结构的平均偏差的方式放置对齐间隙。该残基编号方案应用于 PDB 数据库中的免疫球蛋白可变结构域结构，以自动提取不同分子同源位置的结构变异信息。提出了许多方法，这些方法允许将来自单个结构或来自多结构比对的比较的信息自动投影到序列比对的图形表示上。 (C) 2001 年学术出版社。
A common residue numbering scheme for all immunoglobulin variable domains (immunoglobulin light chain lambda (V-lambda) and kappa (V-kappa) variable domains, heavy chain variable domains (V-H) and T-cell receptor alpha (V-alpha), beta (V-beta), gamma (V-gamma) and delta (V-delta) variable domains) has been devised. Based on the spatial alignment of known three-dimensional structures of immunoglobulin domains, it places the alignment gaps in a way that minimizes the average deviation from the averaged structure of the aligned domains. This residue numbering scheme was applied to the immunoglobulin variable domain structures in the PDB database to automate the extraction of information on structural variations in homologous positions of the different molecules. A number of methods are presented that allow the automated projection of information derived from individual structures or from the comparison of multi-structure alignments onto a graphical representation of the sequence alignment. (C) 2001 Academic Press.