The role of cell adhesion molecules in visual circuit formation: from neurite outgrowth to maps and synaptic specificity.
The role of cell adhesion molecules in visual circuit formation: from neurite outgrowth to maps and synaptic specificity.
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DOI：
10.1002/dneu.22267
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发表时间：
2015-06
影响因子：
3
通讯作者：
Hindges R
中科院分区：
文献类型：
--
作者：
Missaire M;Hindges R
视觉回路的形成是一个多步骤的过程，涉及基于一系列分子机制的细胞间相互作用。个体事件的正确实施，包括轴突生长和指导，地形图的形成，或特定细胞亚型的突触靶向，是功能齐全的视觉系统能够适当处理眼睛捕获的信息的先决条件。细胞粘附分子（CAM）具有粘附特性和高度的功能多样性，已被确定为这些基本过程中的几个关键因素。由于它们的生长促进特性，CAM在神经突发生中起着重要作用。此外，它们对于控制额外的神经突发育、调节树突间距和轴突寻路是必要的。最后，CAM的跨突触相互作用确保了细胞类型特异性连接，作为建立处理不同视觉特征的电路的基础。最近的发现暗示CAM在新的机制，导致更好地了解神经回路的形成，但也揭示了越来越复杂的功能。本文旨在描述CAM塑造神经连接的不同水平的作用，特别关注视觉系统。© 2015 Wiley Periodicals，Inc.开发神经生物学75：569-583，2015年
The formation of visual circuitry is a multistep process that involves cell–cell interactions based on a range of molecular mechanisms. The correct implementation of individual events, including axon outgrowth and guidance, the formation of the topographic map, or the synaptic targeting of specific cellular subtypes, are prerequisites for a fully functional visual system that is able to appropriately process the information captured by the eyes. Cell adhesion molecules (CAMs) with their adhesive properties and their high functional diversity have been identified as key actors in several of these fundamental processes. Because of their growth‐promoting properties, CAMs play an important role in neuritogenesis. Furthermore, they are necessary to control additional neurite development, regulating dendritic spacing and axon pathfinding. Finally, trans‐synaptic interactions of CAMs ensure cell type‐specific connectivity as a basis for the establishment of circuits processing distinct visual features. Recent discoveries implicating CAMs in novel mechanisms have led to a better general understanding of neural circuit formation, but also revealed an increasing complexity of their function. This review aims at describing the different levels of action for CAMs to shape neural connectivity, with a special focus on the visual system. © 2015 Wiley Periodicals, Inc. Develop Neurobiol 75: 569–583, 2015