UNCOUPLING OF CARDIAC-CELLS BY FATTY-ACIDS - STRUCTURE-ACTIVITY-RELATIONSHIPS
UNCOUPLING OF CARDIAC-CELLS BY FATTY-ACIDS - STRUCTURE-ACTIVITY-RELATIONSHIPS
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DOI：
10.1152/ajpcell.1991.260.3.c439
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发表时间：
1991-03-01
影响因子：
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通讯作者：
MINNICH, BN
中科院分区：
文献类型：
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作者：
BURT, JM;MASSEY, KD;MINNICH, BN
油酸以剂量和时间依赖性方式快速且可逆地降低新生大鼠心脏细胞对之间间隙连接的通透性和电导。 其他不饱和脂肪酸（C-18：顺式 6、9 或 11，以及 C-18、16 和 14、顺式 9）、饱和脂肪酸（C-10、12 和 14）和饱和脂肪醇（C-8、10 和 12）也会引起解偶联。 不饱和和饱和脂肪酸和饱和脂肪醇系列的最有效的化合物在相当的水浓度下引起基本上完全解偶联。 然而，油酸在膜浓度低至 1 mol% 时即可解偶联细胞，而癸酸则需要高达 35 mol%。 支持动作电位的通道在相同的膜浓度下仍保持功能。 根据这些化合物引起解偶联的可能机制以及非酯化游离脂肪酸解偶联在缺血性损伤期间和之后引发心律失常中的可能作用来讨论数据。
The permeability and conductance of gap junctions between pairs of neonatal rat heart cells were rapidly and reversibly decreased by oleic acid in a dose- and time-dependent manner. Other unsaturated fatty acids (C-18: cis 6, 9, or 11, and C-18, 16, and 14, cis 9), saturated fatty acids (C-10, 12, and 14), and saturated fatty alcohols (C-8, 10, and 12) also caused uncoupling. The most effective compounds of the unsaturated and saturated fatty acid and saturated fatty alcohol series caused essentially complete uncoupling at comparable aqueous concentrations. However, oleic acid uncoupled cells at membrane concentrations as low as 1 mol%, whereas decanoic acid required upwards of 35 mol%. The channels that support the action potential remained functional at these same membrane concentrations. The data are discussed in terms of the possible mechanism by which these compounds cause uncoupling and the possible role of uncoupling by nonesterified free fatty acids in the initation of arrhythmias during and after ischemic insults.