SELF-ASSOCIATION OF DOXORUBICIN AND RELATED-COMPOUNDS IN AQUEOUS-SOLUTION
SELF-ASSOCIATION OF DOXORUBICIN AND RELATED-COMPOUNDS IN AQUEOUS-SOLUTION
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DOI：
10.1002/jps.2600730615
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发表时间：
1984-01-01
影响因子：
3.8
通讯作者：
ARCAMONE, F
中科院分区：
文献类型：
--
作者：
MENOZZI, M;VALENTINI, L;ARCAMONE, F
The dimerization of doxorubicin, daunorubicin, and their 4‐demethoxy, 4′‐epi, and 4′‐deoxy analogues was studied spectrophotometrically. Self‐association was found to be influenced by buffer composition and ionic strength.Kdvalues were 1.3 × 104and 2.3 × 104M−1for doxorubicin and daunorubicin, respectively, and ranged from 3.8 × 103to 6.1 × 103M−1for the 4‐demethoxy analogues. For 4′‐epi‐ and 4′‐deoxydoxorubicin, tetramerization has also been considered. On this basis, values of 2.0 × 104and 2.2 × 104M−1were found, respectively, for the formation constant of the dimerization process. Stability of the dimeric species appears to be strongly influenced by substitution of the chromophore moiety.
