Controlled ultrasound tissue erosion.
Controlled ultrasound tissue erosion.
复制标题
受控超声组织侵蚀。
DOI：
10.1109/tuffc.2004.1308731
复制
发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Cain,CharlesA
中科院分区：
文献类型：
--
作者：
Xu,Zhen;Ludomirsky,Achiau;Eun,LucyY;Hall,TimothyL;Tran,BinhC;Fowlkes,JBrian;Cain,CharlesA
研究了超声产生高度受控的组织侵蚀的能力。本研究的动机是需要开发一种非侵入性的程序，以重建新生儿房间隔作为治疗左心发育不良综合征的第一步。用788 kHz单探头在40块离体猪心房壁上共产生232个孔。各种参数的影响[例如，研究了脉冲重复频率（PRF）、脉冲宽度（PD）和液体含气量对冲蚀率和能量效率的影响。使用9000 W/cm/sup 2/的Isppa，3、6、12和24个循环的PD; 1.34 kHz和66.7 kHz之间的PRF;以及40-55%和79-85%的气体饱和度。结果表明，在一定的脉冲重复频率下，非常短的脉冲可以最大限度地提高烧蚀率和能量效率。我们表明，明确的穿孔可以通过控制超声组织侵蚀（CUTE）过程中准确地定位在心房壁。对犬受试者进行初步体内实验，并使用CUTE穿孔房间隔。
The ability of ultrasound to produce highly controlled tissue erosion was investigated. This study is motivated by the need to develop a noninvasive procedure to perforate the neonatal atrial septum as the first step in treatment of hypoplastic left heart syndrome. A total of 232 holes were generated in 40 pieces of excised porcine atrial wall by a 788 kHz single-element transducer. The effects of various parameters [e.g., pulse repetition frequency (PRF), pulse duration (PD), and gas content of liquid] on the erosion rate and energy efficiency were explored. An Isppa of 9000 W/cm/sup 2/, PDs of 3, 6, 12, and 24 cycles; PRFs between 1.34 kHz and 66.7 kHz; and gas saturation of 40-55% and 79-85% were used. The results show that very short pulses delivered at certain PRFs could maximize the erosion rate and energy efficiency. We show that well-defined perforations can be precisely located in the atrial wall through the controlled ultrasound tissue erosion (CUTE) process. A preliminary in vivo experiment was conducted on a canine subject, and the atrial septum was perforated using CUTE.