Effect of vagal nerve stimulation on systemic inflammation and cardiac autonomic function in patients with refractory epilepsy
Effect of vagal nerve stimulation on systemic inflammation and cardiac autonomic function in patients with refractory epilepsy
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DOI：
10.1159/000127360
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发表时间：
2008-01-01
影响因子：
2.4
通讯作者：
Crea, Filippo
中科院分区：
文献类型：
--
作者：
Barone, Lucy;Colicchio, Gabriella;Crea, Filippo
目的：最近的数据表明迷走神经刺激（VNS）可以抑制炎症细胞释放细胞因子。因此，最近报道了通过心率变异性（HRV）评估的心脏副交感功能受损与炎症标志物增加之间的关联。在这项研究中，我们评估了直接左侧 VNS 对难治性癫痫患者炎症标志物和 HRV 的影响。方法：对 8 名因难治性癫痫接受 VNS 装置植入的患者（年龄 32 +/- 24 岁，2 名男性）在基线时和左侧 VNS 治疗 3 个月后进行 24 小时动态心电图记录。同时测量肿瘤坏死因子-α、白细胞介素-6 和 C 反应蛋白血清水平，作为炎症标志物。结果：左侧 VNS 3 个月后，与基线相比，HRV 变量和炎症标志物均未发现显着变化。此外，这些患者的 HRV 参数和炎症标志物之间没有一致的相关性。结论：我们对无心血管疾病的癫痫患者的数据未能显示短期随访中左侧 VNS 对心脏自主功能和全身炎症的显着影响。版权所有 (c) 2008 S. Karger AG，巴塞尔。
Objective: Recent data suggest that vagus nerve stimulation (VNS) can inhibit cytokine release by inflammatory cells. Accordingly, an association between impaired cardiac para-sympathetic function, as assessed by heart rate variability (HRV), and increased markers of inflammation has recently been reported. In this study we assessed the effect of direct left VNS on inflammatory markers and HRV in patients with refractory epilepsy. Methods: A 24-hour electrocardiogram Holter recording was performed both at baseline and after 3 months of left VNS in 8 patients (age 32 +/- 24 years, 2 men) who underwent implantation of a VNS device because of refractory epilepsy. Tumor necrosis factor-alpha, interleukin-6 and C-reactive protein serum levels were measured, as markers of inflammation, at the same times. Results: No significant changes were found after 3 months of left VNS, compared to baseline, both for HRV variables and inflammatory markers. Also, no consistent correlation could be demonstrated between HRV parameters and inflammatory markers in these patients. Conclusions: Our data in epileptic patients without cardiovascular disease failed to show a significant effect of left VNS on cardiac autonomic function and on systemic inflammation at short-term follow-up. Copyright (c) 2008 S. Karger AG, Basel.