What is polycystic ovary syndrome? Are national views important?
What is polycystic ovary syndrome? Are national views important?
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DOI：
10.1093/humrep/17.9.2219
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发表时间：
2002-09-01
影响因子：
6.1
通讯作者：
Michelmore, K
中科院分区：
文献类型：
--
作者：
Balen, A;Michelmore, K
多囊卵巢综合征（PCOS）是一种真正的综合征，是一种异质性的体征和症状的集合，聚集在一起形成了一种疾病的谱系，其中一些症状轻微，而另一些则有严重的生殖、内分泌和代谢功能紊乱。关于表现型和最近的基因型有很多争论。也有一些人持怀疑态度，他们觉得我们可能看到了现实中“正常”的一端，或者可能是现代肥胖疾病的后果。虽然多囊卵巢是该综合征的中心，但影响其表达的是外部影响，如高胰岛素血症。对多囊卵巢综合征的定义没有达成共识，因此比较流行病学和治疗的研究往往有非常不同的起点，因此无法进行比较。在这次辩论中，我们希望重新探讨我们目前对多囊性卵巢综合征的看法，特别强调英国和欧洲的观点，并邀请其他国家参与讨论，这可能成为国际协商一致意见的基础。
Polycystic ovary syndrome (PCOS) is a true syndrome, being a heterogeneous collection of signs and symptoms that gathered together form a spectrum of a disorder with a mild presentation in some, whilst in others there is a severe disturbance of reproductive, endocrine and metabolic function. There has been much debate about phenotype and, more recently, genotype. There has also been scepticism in some quarters, with a feeling that we may be looking at one end of a spectrum that is in reality 'normal', or perhaps a consequence of the modern disease of obesity. Whilst the polycystic ovary is at the centre of the syndrome, it is external effects such as hyperinsulinism, that influence its expression. There is no consensus on the definition of PCOS and so studies that compare epidemiology and treatments often have very different starting points, and so cannot be compared. In this debate we wish to re-explore our current thinking on PCOS, with a particular emphasis on the British and European perspective and invite others to contribute to the discussion which could form the basis for an international consensus.