Insights into Acinetobacter War-Wound Infections, Biofilms, and Control
Insights into Acinetobacter War-Wound Infections, Biofilms, and Control
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对战争创伤感染、生物膜和控制的见解
DOI：
10.1097/01.asw.0000363527.08501.a3
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发表时间：
2010-04-01
影响因子：
2.4
通讯作者：
Tao Weitao
中科院分区：
文献类型：
--
作者：
Dallo, Shatha F.;Tao Weitao
目的：多重耐药鲍曼不动杆菌与多种传染病相关，从医院内、社区获得性感染到战争或自然灾害后获得的感染。尤其对于有战伤的军人来说，不动杆菌感染是一个巨大的威胁。这种治疗变得极其困难，不仅因为细菌会产生广泛的抗菌药物耐药性，而且因为它还会形成对宿主防御和抗菌治疗具有抵抗力的生物膜。生物膜形成和耐药性等致病因素很可能导致伤口不愈合。本综述虽然重点关注鲍曼不动杆菌感染，但旨在总结关于针对伤口生物膜感染的免疫保护的已知知识，并将这些理解应用于探索战伤感染保护的未知领域。 数据来源和研究选择：通过使用关键词鲍曼不动杆菌、细菌、战伤、烧伤伤口、伤口感染、生物膜、疫苗和免疫，通过http://www.pubmed.gov搜索和选择出版物。所选文献按本文小标题分类。结论：必须制定主动和被动免疫等有效措施来控制多重耐药和顽固鲍曼不动杆菌感染，防止伤口不愈合。作者对模型细菌对烧伤创面相关感染的免疫的理解将有助于在战伤生物膜感染免疫领域的研究进展。
OBJECTIVE: Multidrug-resistant Acinetobacter baumannii is associated with a wide spectrum of infectious diseases ranging from nosocomial, community-acquired infections to those acquired following war or natural disaster. Especially to military personnel with war wounds, Acinetobacter infection is a formidable threat. The treatment has become exceedingly difficult, not only because the bacterium can develop extensive antimicrobial resistance but because it also forms biofilms that are resistant to host defense and antimicrobial treatment. Such causative factors as biofilm formation and resistance are highly likely to lead to nonhealing wounds. This review, although focused on A baumannii infections, aims to summarize what is known about immunization protection against wound biofilm infections and to apply such understanding in exploring the unknown area of war-wound infection protection.DATA SOURCES AND STUDY SELECTION: Publications were searched and selected through http://www.pubmed.gov by using the key words Acinetobacter baumannii, bacteria, war wounds, burn wounds, wound infections, biofilms, vaccines, and immunization. The literature selected was categorized according to the subheadings within this article.CONCLUSIONS: It is imperative to develop such effective measures as active and passive immunization to control multidrug-resistant and tenacious A baumannii infections and to prevent nonhealing wounds. The authors' understanding in immunization against burn wound-related infections by the model bacteria will facilitate research progress in the poorly explored area of immunization against war-wound biofilm infections.