Increased NKCC1 expression in refractory human epilepsy
Increased NKCC1 expression in refractory human epilepsy
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DOI：
10.1016/j.eplepsyres.2007.01.004
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发表时间：
2007-05-01
影响因子：
2.2
通讯作者：
Sisodiya, Sanjay M.
中科院分区：
文献类型：
--
作者：
Sen, Arjune;Martinian, Lillian;Sisodiya, Sanjay M.
阳离子-氯离子共转运体(CCTs)，特别是NKCC1，可能在癫痫的发生中起重要作用。我们对海马区硬化症(HS)或局灶性皮质发育不良(FCD)患者的大样本进行了详细的NKCC1组织学检查，这两种病理通常与耐药癫痫有关。我们一直发现NKCC1在HS和FCD中的免疫反应增强，但在邻近的组织学正常皮质中不表达。我们的结果提示NKCC1可能参与了HS和FCD的发病或病理生理过程，从而为药物耐药癫痫的治疗提供了一个新的治疗靶点。(C)2007 Elsevier B.V.保留所有权利。
Cation-chloride co-transporters; (CCTs), particularly NKCC1, may be important in epileptogenesis. We have performed a detailed histological examination of NKCC1 in large samples of patients with hippocampal sclerosis (HS) or focal cortical dysplasia (FCD), pathologies both commonly associated with pharmacoresistant epilepsy. We consistently found increased immunoreactivity for NKCC1 in HS and FCD, but not in adjacent histologically normal cortex. Our results suggest that NKCC1 might contribute to the pathogenesis or pathophysiology of HS and FCD, thereby potentially offering a new therapeutic target in the treatment of pharmacoresistant epilepsy. (C) 2007 Elsevier B.V. All rights reserved.