A Rheological Study of Biodegradable Injectable PEGMC/HA Composite Scaffolds.
A Rheological Study of Biodegradable Injectable PEGMC/HA Composite Scaffolds.
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作者：
Jiao Y;Gyawali D;Stark JM;Akcora P;Nair P;Tran RT;Yang J
可注射的生物可降解水凝胶，其可以以微创方式递送并原位形成，已经在药物和生物医学应用中发现了许多应用，例如药物递送和组织工程。我们最近开发了一种可原位交联的基于柠檬酸的可生物降解的聚（乙二醇）马来酸盐柠檬酸盐（PEGMC）/羟基磷灰石（HA）复合材料，这显示了用于骨组织工程的前景。在这项研究中，PEGMC/HA复合材料的力学性能进行了研究，在动态线性流变实验。关键参数，如单体比例，交联剂，引发剂，和HA浓度的变化，以揭示其对交联程度的影响，因为它们控制所得凝胶的机械性能。流变学研究，第一次，使我们能够调查HA和柠檬酸为基础的PEGMC之间的物理相互作用。了解可注射凝胶复合材料的粘弹性对于制备合适的可注射PEGMC/HA骨组织工程支架至关重要，并且还应该促进基于柠檬酸的可生物降解聚合物的其他生物医学应用。
Injectable biodegradable hydrogels, which can be delivered in a minimally invasive manner and formed in situ, have found a number of applications in pharmaceutical and biomedical applications, such as drug delivery and tissue engineering. We have recently developed an in situ crosslinkable citric acid-based biodegradable poly (ethylene glycol) maleate citrate (PEGMC)/hydroxyapatite (HA) composite, which shows promise for use in bone tissue engineering. In this study, the mechanical properties of the PEGMC/HA composites were studied in dynamic linear rheology experiments. Critical parameters such as monomer ratio, crosslinker, initiator, and HA concentrations were varied to reveal their effect on the extent of crosslinking as they control the mechanical properties of the resultant gels. The rheological studies, for the first time, allowed us investigating the physical interactions between HA and citric acid-based PEGMC. Understanding the viscoelastic properties of the injectable gel composites is crucial in formulating suitable injectable PEGMC/HA scaffolds for bone tissue engineering, and should also promote the other biomedical applications based on citric acid-based biodegradable polymers.