The role of clonality in the global spread of fluoroquinolone-resistant bacteria.
The role of clonality in the global spread of fluoroquinolone-resistant bacteria.
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克隆性在氟喹诺酮耐药细菌全球传播中的作用。
DOI：
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发表时间：
2003
影响因子：
11.8
通讯作者：
K. Klugman
中科院分区：
文献类型：
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作者：
K. Klugman
许多细菌对氟喹诺酮类药物耐药的分子流行病学研究表明，耐药性的持续和传播与少数高度成功的细菌克隆有关。最近在全球肺炎球菌克隆中对氟喹诺酮类耐药菌株的描述增加了肺炎球菌对氟喹诺酮类药物耐药的比例将增加的可能性，因为这类药物越来越多地用于成人呼吸道感染的治疗。虽然这些克隆在儿童中仍然对氟喹诺酮类药物敏感，但它们的广泛分布反对将氟喹诺酮类药物用于儿童呼吸道感染的治疗。
The molecular epidemiology of fluoroquinolone resistance in a number of bacterial pathogens suggests that the persistence and spread of resistance is associated with a small number of highly successful bacterial clones. The recent description of fluoroquinolone-resistant strains among global clones of pneumococci raises the likelihood that the percentage of pneumococci resistant to fluoroquinolones will increase as this class of agent is increasingly used for the management of respiratory tract infection in adults. Although these clones remain fluoroquinolone susceptible in children, their widespread distribution argues against the extension of fluoroquinolone use to the management of respiratory tract infection in children.
DOI：
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发表时间：
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期刊：
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影响因子：
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作者：
D. Oliveira;A. Tomasz;H. de Lencastre
通讯作者：
D. Oliveira;A. Tomasz;H. de Lencastre