Aciculitins A-C: Cytotoxic and antifungal cyclic peptides from the lithistid sponge Aciculites orientalis
Aciculitins A-C: Cytotoxic and antifungal cyclic peptides from the lithistid sponge Aciculites orientalis
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DOI：
10.1021/ja953628w
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发表时间：
1996-05-08
影响因子：
15
通讯作者：
Faulkner, DJ
中科院分区：
文献类型：
--
作者：
Bewley, CA;He, HY;Faulkner, DJ
石海绵Aciculites orientalis含有三个环肽，aciculitins A-C（1-3），除了同源的脂质残基外，它们是相同的。通过光谱数据的解释阐明了主要肽Aciculitin B（2）的结构。针状肽由一个含有不寻常的组氨酸-酪氨酸桥的双环肽组成。与双环肽连接的是在3位带有D-来苏糖的C-13-C-15 2，3-二羟基-4，6-二烯酸。还提供了Aciculitamides A（4）和B（5）的结构，它们是早先从这种海绵中获得的人工产物。Aciculitins 1- 3抑制白色念珠菌的生长，并对HCT-116细胞株具有细胞毒性。
The lithistid sponge Aciculites orientalis contains three cyclic peptides, aciculitins A-C (1-3), that are identical except for homologous lipid residues. The structure of the major peptide, aciculitin B (2), was elucidated by interpretation of spectroscopic data. The aciculitins consist of a bicyclic peptide that contains an unusual histidino-tyrosine bridge. Attached to the bicyclic peptide are C-13-C-15 2,3-dihydroxy-4,6-dienoic acids bearing D-lyxose at the 3-position. The structures of aciculitamides A (4) and B (5), which are artifacts obtained earlier from this sponge, are also presented. The aciculitins 1--3 inhibited the growth of Candida albicans and were cytotoxic toward the HCT-116 cell line.