Effect of ethanol on endogenous rhythms of growth hormone secretion.
Effect of ethanol on endogenous rhythms of growth hormone secretion.
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乙醇对生长激素分泌内源节律的影响。
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
G. Redmond
中科院分区：
文献类型：
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作者：
G. Redmond
关于乙醇对生长激素 (GH) 释放影响的人体研究尚未得出结论。为了研究乙醇对 GH 自发性间歇性分泌的影响，给大鼠植入慢性颈动脉导管，以便对未麻醉的大鼠进行频繁采样。通过每 15 分钟抽取样品来评估乙醇或盐水之前（0--180 分钟）和之后（181--360 分钟）3 小时的分泌。盐水或乙醇 0.5 和 2 g/kg 后的分泌模式无法区分，但剂量为 3 和 4 g/kg 的乙醇消除了大多数动物的大鼠 GH (rGH) 分泌。注射盐水后 181--360 分钟的平均 rGH 为 62 +/- 9 ng/ml。当给予乙醇时，该时间段的平均 rGH 值为 0.5 g/kg, 63 +/- 6 ng/ml； 2.0 克/千克，47 +/- 7 纳克/毫升； 3克/公斤，28+/-3纳克/毫升；和 4 克/千克，23 +/- 2 纳克/毫升。盐水与 0.5 或 2 g/kg 乙醇之间的差异不具有统计学显着性，但对于 3 或 4 g/kg 乙醇而言差异显着（p 小于 0.01）。因此，单剂量的乙醇可以消除自发的rGH分泌，但必须是高剂量。长期服用乙醇的效果仍有待研究。
Studies in man on the effect of ethanol on growth hormones (GH) release have been inconclusive. In order to investigate the effect of ethanol on spontaneous episodic secretion of GH, rats were implanted with chronic carotid catheters to permit frequent sampling in unanesthetized rats. Secretion during the 3 hr before (0--180 min) and after (181--360 min) ethanol or saline was assessed by means of samples drawn every 15 min. Secretion patterns after saline or ethanol 0.5 and 2 g/kg were indistinguishable, but ethanol in doses of 3 and 4 g/kg abolished rat GH (rGH) secretion in a majority of animals. Mean rGH after saline injection for the period 181--360 min was 62 +/- 9 ng/ml. When ethanol was given, mean rGH values for this time period were 0.5 g/kg, 63 +/- 6 ng/ml; 2.0 g/kg, 47 +/- 7 ng/ml; 3 g/kg, 28 +/- 3 ng/ml; and 4 g/kg, 23 +/- 2 ng/ml. Differences were not statistically significant between saline and 0.5 or 2 g/kg ethanol, but were significant (p less than 0.01) for 3 or 4 g/kg ethanol. Thus, a single dose of ethanol can abolish spontaneous rGH secretion, but it must be a high dose. The effect of chronic ethanol administration remains to be investigated.