Gender has no influence on mortality after burn injuries: A 20-year single center study with 839 patients
Gender has no influence on mortality after burn injuries: A 20-year single center study with 839 patients
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DOI：
10.1016/j.burns.2018.08.012
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发表时间：
2019-02-01
期刊：
影响因子：
2.7
通讯作者：
Pauzenberger, Reinhard
中科院分区：
文献类型：
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作者：
Ederer, Ines A.;Hacker, Stefan;Pauzenberger, Reinhard
背景：根据ABSI（缩写烧伤严重程度指数），女性死于烧伤的风险增加。相比之下，在非热创伤后，男性的死亡率增加。因此，本研究的目的是评估烧伤患者之间的性别差异，特别是烧伤死亡率。方法：我们回顾性研究了1994年6月至2014年12月期间入住烧伤重症监护病房（BICU）并接受手术治疗的839名患者。院内死亡率是主要临床终点。使用单变量和多变量 Logistic 回归模型计算性别与死亡率之间的比值比 (OR)。结果：我们总共纳入了 530 名男性和 309 名女性烧伤患者。所有患者都至少有部分皮层烧伤，并接受了一项或多项手术。女性明显比男性年龄大（平均 60.0 岁 vs 46.2 岁；p < 0.001）。尽管损伤较小（总体表面积 (TBSA) 为 24.6% vs 30.3%；p < 0.001），但女性烧伤死亡率与男性有显着差异（27.8% vs 21.7%；OR 1.39，p = 0.045，95% CI 1.01-1.92）。然而，在调整年龄、%TBSA、吸入性损伤和全层烧伤后，这种相关性并没有持续存在（OR 1.07，p = 0.77，95% CI 0.68-1.70）。结论：尽管针对女性健康的研究不断增加，但性别与烧伤死亡率之间的关联却产生了相互矛盾的结果。这项研究不支持我们的研究人群烧伤死亡率存在性别差异。 (C) 2018 Elsevier Ltd 和 ISBI。版权所有。
Background: According to the ABSI - Abbreviated Burn Severity Index - women exhibit an increased risk of succumbing to burn injuries. In contrast, following non-thermal trauma, increased mortality has been shown for the male gender. Therefore, the purpose of this study was to evaluate gender-specific differences among burn patients with special regard to burn mortality.Methods: We retrospectively studied 839 patients who were admitted to the Burn Intensive Care Unit (BICU) and underwent surgical treatment between June 1994 and December 2014. In-hospital mortality was the main clinical endpoint. Odds ratios (ORs) were calculated using univariate and multivariate logistic regression models for the association between sex and mortality.Results: In total, we included 530 male and 309 female burn patients. All patients had at least partial-thickness burns and underwent one or more operative procedures. Women were significantly older than men (mean 60.0 years us 46.2 years; p < 0.001). Despite having smaller injuries (24.6% vs 30.3% total body surface area (TBSA); p < 0.001), burn mortality among women significantly differed from that of men (27.8% vs 21.7%; OR 1.39, p = 0.045,95% CI 1.01-1.92). This association, however, did not persist after adjusting for age, %TBSA, inhalation injury and full-thickness burns (OR 1.07, p = 0.77, 95% CI 0.68-1.70).Conclusions: Despite increasing research directed at women's health, the assoziation between gender and burn mortality has yielded conflicting results. This study does not support a gender-specific difference in burn mortality in our study population. (C) 2018 Elsevier Ltd and ISBI. All rights reserved.