Cytotoxic and antiviral nitrobenzoyl sesquiterpenoids from the marine-derived fungus Aspergillus ochraceus Jcma1F17
Cytotoxic and antiviral nitrobenzoyl sesquiterpenoids from the marine-derived fungus Aspergillus ochraceus Jcma1F17
复制标题
来自海洋源性真菌赭曲霉 Jcma1F17 的细胞毒性和抗病毒硝基苯甲酰倍半萜类化合物
DOI：
10.1039/c3md00371j
复制
发表时间：
2014-06-01
期刊：
影响因子：
--
通讯作者：
Liu, Yonghong
中科院分区：
文献类型：
--
作者：
Fang, Wei;Lin, Xiuping;Liu, Yonghong
硝基苯甲酰类倍半萜在天然来源中十分罕见，真菌曲霉属是其唯一的来源。从海洋真菌赭曲霉（Aspergillus ochraceus）Jcma 1F 17的培养物中分离得到一个新的硝基苯甲酰倍半萜类化合物6 β，9 α-二羟基-14-对硝基苯甲酰肉桂醛（1）和一个已知的类似物insuliclavin A（2），并通过形态学和ITS系统发育分析鉴定了其结构。通过NMR、MS、CD和旋光度分析确定了其结构。两种硝基苯甲酰倍半萜类化合物对10种肿瘤细胞株均表现出明显的细胞毒活性，新化合物（1）对H3 N2和EV 71也表现出抗病毒活性。这是首次从A.已经报道了赭石病。
Nitrobenzoyl sesquiterpenoids are rare in natural sources, and fungi Aspergillus species are the only sources of them. A new nitrobenzoyl sesquiterpenoid, 6 beta, 9 alpha-dihydroxy-14-p-nitrobenzoylcinnamolide (1), and a known analogue, insulicolide A (2), were isolated from extracts of the culture of marine-derived fungus Aspergillus ochraceus Jcma1F17, which was identified by morphological and ITS phylogenetic analyses. The structures were determined by NMR, MS, CD, and optical rotation analyses. Both nitrobenzoyl sesquiterpenoids displayed significant cytotoxicities against 10 cancer cell lines, and the new one (1) also showed antiviral activities against H3N2 and EV71. This is the first time that nitrobenzoyl sesquiterpenoids from A. ochraceus have been reported.