ADRENERGIC-RECEPTORS IN PARKINSONS-DISEASE
ADRENERGIC-RECEPTORS IN PARKINSONS-DISEASE
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DOI：
10.1016/0006-8993(84)90117-3
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发表时间：
1984-01-01
期刊：
影响因子：
2.9
通讯作者：
AGID, Y
中科院分区：
文献类型：
--
作者：
CASH, R;RUBERG, M;AGID, Y
在帕金森病患者死后的前额皮质中测量α 1、α 2、β 1和β 2肾上腺素能受体。在对照和帕金森病患者中β 2受体的数量是相同的。α 1和β 1受体的数量增加，特别是在帕金森痴呆患者中，而α 2受体减少。亲和常数不变。这些变化可能与蓝斑至皮质的去甲肾上腺素能通路受损有关。此病变和帕金森病患者的痴呆和抑郁症状之间的关系进行了讨论。
.alpha.1, .alpha.2, .beta.1 and .beta.2 Adrenergic receptors were measured in the pre-frontal cortex of parkinsonian patients post-mortem. The number of .beta.2 receptors was the same in control and parkinsonian subjects. .alpha.1 and .beta.1 Receptors increased in number, particularly in demented parkinsonian patients, while .alpha.2 receptors decreased. The affinity constants were unchanged. The modifications seem to be related to lesion of the noradrenergic pathway from the locus coeruleus to the cortex. The relationship between this lesion and the symptoms of dementia and depression in parkinsonian patients is discussed.