Evidence of Toscana virus infections without central nervous system involvement: A serological study
Evidence of Toscana virus infections without central nervous system involvement: A serological study
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DOI：
10.1023/a:1007422103992
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发表时间：
1997-10-01
影响因子：
13.6
通讯作者：
Ciufolini, MG
中科院分区：
文献类型：
--
作者：
Braito, A;Corbisiero, R;Ciufolini, MG
在意大利中部，由于白蛉属传播的病毒（白蛉病毒托斯卡纳，TOSv）引起的急性淋巴细胞性脑膜炎和脑膜脑炎在整个夏季经常发生。有病毒性脑膜炎/脑膜脑炎临床表现的住院患者的几份血清标本显示抗TOS-IgG反应性，提示在过去未知时间发生的既往感染。这一观察结果使我们设计了一个血清学调查的83个家庭接触的46个夏季中枢神经系统感染患者（索引案件）的目的是评估的百分比IgG和IgM的血清阳性的健康个体，生活在高风险的地区白蛉叮咬的索引案件。使用ELISA方法进行血清学研究：22%的血清显示出抗TOS IgG抗体的反应性，6%的血清呈IgG/IgM阳性;他们中没有人报告有任何CNS受累的症状;血清阳性病例的分布在TOS确认和TOS阴性病例的接触者中相似。我们的结果表明：（1）Toscana白蛉病毒托斯卡纳经常与CNS疾病以及不涉及神经系统的感染有关;（2）在我国，生态要求包括人类住区内和周围的条件，使白蛉成为周栖，从而放大了TOSv感染的风险，实际上，TOSv感染在锡耶纳及其周围地区广泛和频繁。
In central Italy, acute lymphocytic meningitis and meningoencephalitis due to a Phlebotomus transmitted virus (Phlebovirus Toscana, TOSv) occurring throughout the summer are frequently observed. Several serum specimens of patients hospitalized with a clinical picture of viral meningitis/meningoencephalitis showed anti TOS-IgG reactivity suggestive of a previous infection occurring at an unknown time in the past. This observation led us to design a serological investigation of 83 household contacts of 46 summertime CNS infection patients (index cases) with the purpose of evaluating the percentage of both IgG and IgM in seropositive healthy individuals, living, like the index cases, in areas at high risk of phlebotomine sandfly bites. The serological study was carried out using an ELISA method: 22% of the sera showed a reactivity for anti-TOS IgG antibodies and 6% resulted IgG/IgM positive; none of them reported having had any symptoms of CNS involvement; the distribution of seropositive cases was similar in contacts of both TOS-confirmed and TOS-negative cases. Our results indicate: (1) that phlebovirus Toscana is frequently implicated in cases with CNS disease as well as in infections occurring without neurological involvement; (2) in our country the ecological requirements encompass the conditions in and around the human settlements for phlebotomine sandflies to become peridomestic thus amplifying the risk of TOSv infections, which are in fact widespread and frequent in Siena and its surroundings.