Longitudinal psychophysiological studies of heart rate: Mediating effects and implications for treatment
Longitudinal psychophysiological studies of heart rate: Mediating effects and implications for treatment
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DOI：
10.1196/annals.1364.002
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发表时间：
2006-01-01
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影响因子：
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通讯作者：
Bryant, Richard A.
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文献类型：
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作者：
Bryant, Richard A.
创伤后应激障碍(PTSD)的恐惧条件模型认为，创伤时去甲肾上腺素的激活导致创伤记忆的过度巩固，从而导致创伤后应激障碍。这一模型表明，创伤后急性期的静息心率(HR)可能反映去甲肾上腺素反应的强度，并可能代表那些有创伤后应激障碍发展风险的人的初始标志。报告了十项前瞻性研究，评估了创伤后一周内静息心率与随后的创伤后应激障碍的关系。虽然10项研究中有8项发现急性期心率升高与随后的创伤后应激障碍风险增加相关，但在心率水平和随后的创伤后应激障碍之间存在很大的差异。目前的数据表明，创伤后应激障碍的发展有多种途径，但不一定会导致心率升高。数据表明，急性期的HR不能准确地识别有创伤后应激障碍风险的人。人力资源和创伤后应激障碍之间的联系确实表明，人力资源是测试创伤反应的恐惧条件反射模型的有用手段。
Fear conditionings models of posttraumatic stress disorder (PTSD) propose that noradrenergic activation at the time of trauma leads to overconsolidation of trauma memories and contributes to PTSD. This model suggests that resting heart rate (HR) in the acute phase after trauma may reflect the strength of the noradrenergic response and may represent an initial marker of those who are at risk of PTSD development. Ten prospective studies are reported that assessed the relationship of resting HR within I week of trauma and subsequent PTSD. Whereas 8 of the 10 studies found that elevated HR in the acute phase was associated with increased risk of subsequent PTSD, there was much variability in the HR levels and subsequent PTSD. The current data suggest multiple pathways to PTSD development that may not necessarily involve elevated HR. The data indicate that HR in the acute phase cannot be accurately used to identify people who are at risk for PTSD. The association between HR and PTSD does suggest that HR is a useful means to test fear conditioning models of trauma response.